A Comparison of Short Versus Long Course Intravenous Antibiotics When Treating Urinary Tract Infection in Infants <60 Days of Age.


Journal

Clinical pediatrics
ISSN: 1938-2707
Titre abrégé: Clin Pediatr (Phila)
Pays: United States
ID NLM: 0372606

Informations de publication

Date de publication:
10 2023
Historique:
medline: 4 9 2023
pubmed: 22 2 2023
entrez: 21 2 2023
Statut: ppublish

Résumé

Urinary tract infections (UTIs) are a common reason for hospitalization in infants younger than 60 days, and the optimal approach to intravenous (IV) antibiotic therapy upon UTI diagnosis in this cohort is unknown. We determined whether there was an association between IV antibiotic therapy duration (long [>3 days] vs short [≤3 days]) and treatment failure via a retrospective review of infants with confirmed UTIs receiving IV antibiotics at a tertiary referral center. A total of 403 infants were included; 39% were treated with ampicillin and cefotaxime, and 34% with ampicillin and gentamycin or tobramycin. The median IV antibiotic duration was 5 (interquartile range: 3-10) days, and 5% of patients experienced treatment failure. The treatment failure rate was similar in both short- and long-course IV antibiotic groups (

Identifiants

pubmed: 36803102
doi: 10.1177/00099228231154364
pmc: PMC10478320
doi:

Substances chimiques

Anti-Bacterial Agents 0
Gentamicins 0
Ampicillin 7C782967RD

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1201-1208

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Auteurs

Fadi Zu'bi (F)

Department of Urology, Rambam Health Care Campus, Haifa, Israel.
Department of Urology, The Nazareth Hospital EMMS, Nazareth, Israel.

Martha Pokarowski (M)

Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada.

Rusul Al-Kutbi (R)

Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada.

Michelle Science (M)

Division of Infectious Diseases, The Hospital for Sick Children, Toronto, ON, Canada.

Janaki Vallipuram (J)

Division of Paediatric Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

Fardod O'Kelly (F)

Division of Urology, Beacon Hospital, University College Dublin, Dublin, Ireland.

Michael Chua (M)

Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada.

Jeremy Friedman (J)

Division of Infectious Diseases, The Hospital for Sick Children, Toronto, ON, Canada.

Martin Koyle (M)

Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada.

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Classifications MeSH