Neoadjuvant immune-checkpoint inhibitors in lung cancer - a primer for radiologists.

Humans Immune Checkpoint Inhibitors Carcinoma, Non-Small-Cell Lung / pathology Neoadjuvant Therapy / methods Immunotherapy / methods Lung Neoplasms / diagnostic imaging Radiologists
Immune-checkpoint inhibitor therapy Immunotherapy Lung cancer NSCLC Neoadjuvant PET-CT Response

Journal

European journal of radiology
ISSN: 1872-7727
Titre abrégé: Eur J Radiol
Pays: Ireland
ID NLM: 8106411

Informations de publication

Date de publication:
Apr 2023
Historique:
received: 01 02 2023
accepted: 03 02 2023
pubmed: 23 2 2023
medline: 21 3 2023
entrez: 22 2 2023
Statut: ppublish

Résumé

The introduction of neoadjuvant immune checkpoint inhibitors plus platinum-based chemotherapy has changed treatment regimens of patient's early-stage lung cancer. This treatment combination induces high rates of complete pathologic response and improves clinical endpoints. Imaging plays a fundamental role in assessment of treatment response, monitoring of (immune-related) adverse events and enables both the surgeon and pathologist optimal treatment and diagnostic workup of the resected tumor samples. Knowledge of the strengths and weaknesses of diagnostic imaging in this setting are essential for radiologists to provide valuable input in multidisciplinary team decisions.

Identifiants

DOI: 10.1016/j.ejrad.2023.110732 PMID: 36804313
pubmed: 36804313
pii: S0720-048X(23)00046-3
doi: 10.1016/j.ejrad.2023.110732
pii:
doi:

Substances chimiques

Immune Checkpoint Inhibitors 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

110732

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper: [Helmut Prosch reports financial support was provided by Christian Doppler Laboratories. Lucian Beer reports a relationship with Bayer, Novartis, MSD, Roche that includes: speaking and lecture fees and travel reimbursement].

Auteurs

Daria Kifjak (D)

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Machine Learning Driven Precision Imaging, Medical University of Vienna, Vienna, Austria; Department of Radiology, UMass Memorial Medical Center and University of Massachusetts Chan Medical School, Worcester, MA, USA.

Maximilian J Hochmair (MJ)

Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna, Austria; Department of Respiratory and Critical Care Medicine, Klinik Floridsdorf, Vienna Healthcare Group, Vienna, Austria.

Dagmar Krenbek (D)

Department of Pathology, Klinik Floridsdorf, Vienna Healthcare Group, Vienna, Austria.

Ruxandra-Iulia Milos (RI)

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Machine Learning Driven Precision Imaging, Medical University of Vienna, Vienna, Austria.

Benedikt H Heidinger (BH)

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Machine Learning Driven Precision Imaging, Medical University of Vienna, Vienna, Austria.

Florian Prayer (F)

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Machine Learning Driven Precision Imaging, Medical University of Vienna, Vienna, Austria.

Sebastian Röhrich (S)

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Machine Learning Driven Precision Imaging, Medical University of Vienna, Vienna, Austria.

Martin L Watzenboeck (ML)

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Machine Learning Driven Precision Imaging, Medical University of Vienna, Vienna, Austria.

Felicitas Oberndorfer (F)

Clinical Institute of Pathology, Medical University Vienna, Vienna, Austria.

Thomas Klikovits (T)

Department of Thoracic Surgery, Klinik Floridsdorf, Vienna Healthcare Group, Vienna, Austria.

Clemens Aigner (C)

Department of Thoracic Surgery, Klinik Floridsdorf, Vienna Healthcare Group, Vienna, Austria.

Katharina Sinn (K)

Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.

Mir Alireza Hoda (MA)

Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.

Konrad Hoetzenecker (K)

Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.

Alexander R Haug (AR)

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.

Helmut Prosch (H)

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Machine Learning Driven Precision Imaging, Medical University of Vienna, Vienna, Austria.

Lucian Beer (L)

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Machine Learning Driven Precision Imaging, Medical University of Vienna, Vienna, Austria. Electronic address: lucian.beer@meduniwien.ac.at.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neoadjuvant immune-checkpoint inhibitors in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Inhibiteurs de points de contrôle immunitaires › Neoadjuvant immune-checkpoint inhibitors in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Neoadjuvant immune-checkpoint inhibitors in...
questionsmedicales.fr › Thérapeutique › Association thérapeutique › Traitement néoadjuvant › Neoadjuvant immune-checkpoint inhibitors in...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Neoadjuvant immune-checkpoint inhibitors in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Neoadjuvant immune-checkpoint inhibitors in...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Personnel de santé › Médecins › Radiologues › Neoadjuvant immune-checkpoint inhibitors in...