Atopic Polygenic Risk Score Is Associated with Paradoxical Eczema Developing in Patients with Psoriasis Treated with Biologics.

Humans Dermatitis, Atopic / complications Eczema / epidemiology Psoriasis / drug therapy Risk Factors Biological Products Netrin Receptors

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
08 2023
Historique:
received: 08 11 2022
revised: 04 01 2023
accepted: 05 01 2023
medline: 18 7 2023
pubmed: 23 2 2023
entrez: 22 2 2023
Statut: ppublish

Résumé

Biologic therapies for psoriasis can cause paradoxical eczema. The role of genetic factors in its pathogenesis is unknown. To identify risk variants, we conducted a GWAS of 3,212 patients with psoriasis, of whom 88 developed paradoxical eczema. Two lead SNPs reached genome-wide significance (P ≤ 5 × 10

Identifiants

DOI: 10.1016/j.jid.2023.01.021 PMID: 36804406
pubmed: 36804406
pii: S0022-202X(23)00077-5
doi: 10.1016/j.jid.2023.01.021
pii:
doi:

Substances chimiques

Biological Products 0
UNC5B protein, human 0
Netrin Receptors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1470-1478.e1

Subventions

Organisme : Medical Research Council
ID : MR/N025989/1
Pays : United Kingdom

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Ali Al-Janabi (A)

Centre for Dermatology Research, Salford Royal NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, The University of Manchester, Manchester, United Kingdom. Electronic address: ali.al-janabi-2@postgrad.manchester.ac.uk.

Steve Eyre (S)

Centre for Dermatology Research, Salford Royal NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, The University of Manchester, Manchester, United Kingdom; Centre for Genetics & Genomics Versus Arthritis, The University of Manchester, Manchester, United Kingdom; Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom.

Amy C Foulkes (AC)

Centre for Dermatology Research, Salford Royal NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, The University of Manchester, Manchester, United Kingdom.

Adnan R Khan (AR)

UCB Biopharma, Slough, United Kingdom.

Nick Dand (N)

Department of Medical & Molecular Genetics, Faculty of Life Sciences and Medicine, School of Basic & Medical Biosciences, King's College London, London, United Kingdom.

Ekaterina Burova (E)

Dermatology, Bedfordshire Hospitals NHS Trust, Bedford, United Kingdom.

Bernadette DeSilva (B)

Department of Dermatology, Luton and Dunstable University Hospital, Luton, United Kingdom.

Areti Makrygeorgou (A)

Dermatology Department, West Ambulatory Care Hospital, Glasgow, United Kingdom.

Emily Davies (E)

Department of Dermatology, Gloucester Royal Hospital, Gloucester, United Kingdom.

Catherine H Smith (CH)

St. John's Institute of Dermatology, Faculty of Life Sciences and Medicine, School of Basic and Medical Biosciences, King's College London, London, United Kingdom; St. John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

Christopher E M Griffiths (CEM)

Centre for Dermatology Research, Salford Royal NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, The University of Manchester, Manchester, United Kingdom.

Andrew P Morris (AP)

Centre for Genetics & Genomics Versus Arthritis, The University of Manchester, Manchester, United Kingdom; Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom.

Richard B Warren (RB)

Centre for Dermatology Research, Salford Royal NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, The University of Manchester, Manchester, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Atopic Polygenic Risk Score Is Associated with...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Eczéma atopique › Atopic Polygenic Risk Score Is Associated with...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses eczémateuses › Eczéma › Atopic Polygenic Risk Score Is Associated with...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › Atopic Polygenic Risk Score Is Associated with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Atopic Polygenic Risk Score Is Associated with...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Atopic Polygenic Risk Score Is Associated with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs de la nétrine › Atopic Polygenic Risk Score Is Associated with...