A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans.

Humans Deep Brain Stimulation Mental Disorders / therapy Wearable Electronic Devices

Journal

Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671

Informations de publication

Date de publication:
03 2023
Historique:
received: 24 03 2022
accepted: 17 01 2023
pubmed: 23 2 2023
medline: 10 3 2023
entrez: 22 2 2023
Statut: ppublish

Résumé

Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species.

Identifiants

DOI: 10.1038/s41593-023-01260-4 PMID: 36804647 PMC: PMC9991917
pubmed: 36804647
doi: 10.1038/s41593-023-01260-4
pii: 10.1038/s41593-023-01260-4
pmc: PMC9991917
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

517-527

Subventions

Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : NS103780
Organisme : NINDS NIH HHS
ID : K99 NS126715
Pays : United States
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : NS084017
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : F30MH125534
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : NS103802

Informations de copyright

© 2023. The Author(s).

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Auteurs

Uros Topalovic (U)

Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
ORCID: 0000-0003-4005-7979

Sam Barclay (S)

Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.

Chenkai Ling (C)

Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.

Ahmed Alzuhair (A)

Department of Electrical Engineering, King Saud University, Riyadh, Saudi Arabia.
ORCID: 0000-0001-6244-4852

Wenhao Yu (W)

Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.

Vahagn Hokhikyan (V)

Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
ORCID: 0000-0003-2069-7290

Hariprasad Chandrakumar (H)

Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
ORCID: 0000-0003-0758-5534

Dejan Rozgic (D)

Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.

Wenlong Jiang (W)

Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.

Sina Basir-Kazeruni (S)

Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.

Sabrina L Maoz (SL)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Medical Scientist Training Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
ORCID: 0000-0003-2021-4316

Cory S Inman (CS)

Department of Psychology, University of Utah, Salt Lake City, UT, USA.

Matthias Stangl (M)

Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
ORCID: 0000-0002-3331-0510

Jay Gill (J)

Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Medical Scientist Training Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Ausaf Bari (A)

Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Aria Fallah (A)

Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Dawn Eliashiv (D)

Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.

Nader Pouratian (N)

Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, USA.

Itzhak Fried (I)

Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Nanthia Suthana (N)

Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. nanthia@ucla.edu.
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA. nanthia@ucla.edu.
Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. nanthia@ucla.edu.
Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. nanthia@ucla.edu.
ORCID: 0000-0002-8796-3277

Dejan Markovic (D)

Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA. dejan@ucla.edu.
ORCID: 0000-0002-6744-7531

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A wearable platform for closed-loop...
questionsmedicales.fr › Procédures de chirurgie opératoire › Stimulation cérébrale profonde › A wearable platform for closed-loop...
questionsmedicales.fr › Troubles mentaux › A wearable platform for closed-loop...
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures électriques › Dispositifs électroniques portables › A wearable platform for closed-loop...