Identification of Small-Molecule Inhibitors of the Salmonella FraB Deglycase Using a Live-Cell Assay.
FraB
Salmonella
antimicrobial agents
enzyme kinetics
high-throughput screen
sugar-phosphate toxicity
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
21 Feb 2023
21 Feb 2023
Historique:
entrez:
22
2
2023
pubmed:
23
2
2023
medline:
23
2
2023
Statut:
aheadofprint
Résumé
Nontyphoidal salmonellosis is one of the most significant foodborne diseases in the United States and globally. There are no vaccines available for human use to prevent this disease, and only broad-spectrum antibiotics are available to treat complicated cases of the disease. However, antibiotic resistance is on the rise and new therapeutics are needed. We previously identified the Salmonella
Identifiants
pubmed: 36809033
doi: 10.1128/spectrum.04606-22
pmc: PMC10100877
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0460622Subventions
Organisme : NIAID NIH HHS
ID : R01 AI140541
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116119
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143288
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM141955
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM068412
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI165391
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM086252
Pays : United States
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