Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants.

Animals Simian Immunodeficiency Virus / genetics Simian Acquired Immunodeficiency Syndrome Anti-Retroviral Agents / pharmacology Macaca mulatta HIV Infections / drug therapy Proviruses / genetics CD4-Positive T-Lymphocytes Viral Load
SIV clonal expansion decay defective provirus latent reservoir

Journal

Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316

Informations de publication

Date de publication:
08 03 2023
Historique:
received: 19 09 2022
revised: 02 12 2022
accepted: 24 01 2023
pmc-release: 08 03 2024
pubmed: 23 2 2023
medline: 14 3 2023
entrez: 22 2 2023
Statut: ppublish

Résumé

The decay kinetics of HIV-1-infected cells are critical to understand virus persistence. We evaluated the frequency of simian immunodeficiency virus (SIV)-infected cells for 4 years of antiretroviral therapy (ART). The intact proviral DNA assay (IPDA) and an assay for hypermutated proviruses revealed short- and long-term infected cell dynamics in macaques starting ART ∼1 year after infection. Intact SIV genomes in circulating CD4

Identifiants

DOI: 10.1016/j.chom.2023.01.016 PMID: 36809762 PMC: PMC10583177
pubmed: 36809762
pii: S1931-3128(23)00041-0
doi: 10.1016/j.chom.2023.01.016
pmc: PMC10583177
mid: NIHMS1905440
pii:
doi:

Substances chimiques

Anti-Retroviral Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

356-372.e5

Subventions

Organisme : NIAID NIH HHS
ID : P01 AI169615
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI028433
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI087520
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI164570
Pays : United States

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests Aspects of HIV-1 IPDA are subject of a patent application PCT/ US16/28822 filed by Johns Hopkins University. R.F.S. is an inventor on this application. Accelevir Diagnostics holds an exclusive license for this patent application. R.F.S. holds no equity interest in Accelevir Diagnostics.

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Auteurs

Emily J Fray (EJ)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: efray1@jhmi.edu.

Fengting Wu (F)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Francesco R Simonetti (FR)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Carolin Zitzmann (C)

Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Narmada Sambaturu (N)

Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Carmen Molina-Paris (C)

Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Alexandra M Bender (AM)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Po-Ting Liu (PT)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

John D Ventura (JD)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Roger W Wiseman (RW)

Wisconsin National Primate Research Center, Madison, WI 53715, USA.

David H O'Connor (DH)

Wisconsin National Primate Research Center, Madison, WI 53715, USA.

Romas Geleziunas (R)

Gilead Sciences, Foster City, CA 94404, USA.

Thomas Leitner (T)

Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Ruy M Ribeiro (RM)

Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Alan S Perelson (AS)

Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Dan H Barouch (DH)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Janet D Siliciano (JD)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Robert F Siliciano (RF)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA. Electronic address: rsiliciano@jhmi.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Antiretroviral therapy reveals triphasic decay...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Rétrovirus simiens › Virus de l'immunodéficience simienne › Antiretroviral therapy reveals triphasic decay...
questionsmedicales.fr › Maladies de l'animal › Maladies des primates › Maladies des singes › Syndrome d'immunodéficience acquise du singe › Antiretroviral therapy reveals triphasic decay...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Antiretroviral therapy reveals triphasic decay...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Antiretroviral therapy reveals triphasic decay...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Antiretroviral therapy reveals triphasic decay...
questionsmedicales.fr › Virus › Provirus › Antiretroviral therapy reveals triphasic decay...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Antiretroviral therapy reveals triphasic decay...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › Antiretroviral therapy reveals triphasic decay...