Trends and cyclic variation in the incidence of childhood type 1 diabetes in two Italian regions over 33 years and during the COVID-19 pandemic.
COVID-19
incidence
paediatric type 1 diabetes
population
Journal
Diabetes, obesity & metabolism
ISSN: 1463-1326
Titre abrégé: Diabetes Obes Metab
Pays: England
ID NLM: 100883645
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
revised:
09
02
2023
received:
19
12
2022
accepted:
19
02
2023
medline:
4
5
2023
pubmed:
23
2
2023
entrez:
22
2
2023
Statut:
ppublish
Résumé
There is conflicting evidence about the impact of the COVID-19 pandemic on the incidence of type 1 diabetes. Here, we analysed long-term trends in the incidence of type 1 diabetes in Italian children and adolescents from 1989 to 2019 and compared the incidence observed during the COVID-19 pandemic with that estimated from long-term data. This was a population-based incidence study using longitudinal data from two diabetes registries in mainland Italy. Trends in the incidence of type 1 diabetes from 1 January 1989 to 31 December 2019 were estimated using Poisson and segmented regression models. There was a significant increasing trend in the incidence of type 1 diabetes of 3.6% per year [95% confidence interval (CI): 2.4-4.8] between 1989 and 2003, a breakpoint in 2003, and then a constant incidence until 2019 (0.5%, 95% CI: -1.3 to 2.4). There was a significant 4-year cycle in incidence over the entire study period. The rate observed in 2021 (26.7, 95% CI: 23.0-30.9) was significantly higher than expected (19.5, 95% CI: 17.6-21.4; p = .010). Long-term incidence analysis showed an unexpected increase in new cases of type 1 diabetes in 2021. The incidence of type 1 diabetes now needs continuous monitoring using population registries to understand better the impact of COVID-19 on new-onset type 1 diabetes in children.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1698-1703Informations de copyright
© 2023 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.
Références
Patterson CC, Harjutsalo V, Rosenbauer J, et al. Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989-2013: a multicentre prospective registration study. Diabetologia. 2019;62(3):408-417. doi:10.1007/s00125-018-4763-3
Harjutsalo V, Sund R, Knip M, Groop P-H. Incidence of type 1 diabetes in Finland. JAMA. 2013;310(4):427-428. doi:10.1001/jama.2013.8399
Parviainen A, But A, Siljander H, Knip M. Decreased incidence of type 1 diabetes in young finnish children. Diabetes Care. 2020;43(12):2953-2958. doi:10.2337/dc20-0604
Berhan Y, Waernbaum I, Lind T, Möllsten A, Dahlquist G. Thirty years of prospective nationwide incidence of childhood type 1 diabetes: the accelerating increase by time tends to level off in Sweden. Diabetes. 2011;60(2):577-581. doi:10.2337/db10-0813
Skrivarhaug T, Stene LC, Drivvoll AK, Strøm H, Joner G. Incidence of type 1 diabetes in Norway among children aged 0-14 years between 1989 and 2012: has the incidence stopped rising? Results from the Norwegian childhood diabetes registry. Diabetologia. 2014;57(1):57-62. doi:10.1007/s00125-013-3090-y
Norris JM, Johnson RK, Stene LC. Type 1 diabetes-early life origins and changing epidemiology. Lancet Diabetes Endocrinol. 2020;8(3):226-238. doi:10.1016/S2213-8587(19)30412-7
Laitinen OH, Honkanen H, Pakkanen O, et al. Coxsackievirus b1 is associated with induction of β-cells autoimmunity that portends type 1 diabetes. Diabetes. 2014;63(2):446-455. doi:10.2337/db13-0619
Cherubini V, Marino M, Scaramuzza AE, et al. The silent epidemic of diabetic ketoacidosis at diagnosis of type 1 diabetes in children and adolescents in Italy during the COVID-19 pandemic in 2020. Front Endocrinol (Lausanne). 2022;13(June):1-9. doi:10.3389/fendo.2022.878634
Birkebaek N, Kamrath C, Grimsmann J, et al. Long-term trends in the frequency of diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes and impact of the COVID-19 pandemic in 2020 and 2021 - an international multicentre study using 13 national. Lancet Diabetes Endocrinol. 2022;8587(22):1-9. doi:10.1016/S2213-8587(22)00246-7
Unsworth R, Wallace S, Oliver NS, et al. New-onset type 1 diabetes in children during COVID-19: multicenter regional findings in the U.K. Diabetes Care. 2020;43(11):e170-e171. doi:10.2337/dc20-1551
Salmi H, Heinonen S, Hästbacka J, et al. New-onset type 1 diabetes in Finnish children during the COVID-19 pandemic. Arch Dis Child. 2022;107(2):180-185. doi:10.1136/archdischild-2020-321220
Tittel SR, Rosenbauer J, Kamrath C, et al. Did the COVID-19 lockdown affect the incidence of pediatric type 1 diabetes in Germany? Diabetes Care. 2020;43(11):e172-e173. doi:10.2337/dc20-1633
Kamrath C, Rosenbauer J, Eckert AJ, et al. Incidence of type 1 diabetes in children and adolescents during the COVID-19 pandemic in Germany: results from the DPV registry. Diabetes Care. 2022;45:1762-1771. doi:10.2337/dc21-0969
Carle F, Gesuita R, Bruno G, et al. Diabetes incidence in 0- to 14-year age-group in Italy: a 10-year prospective study. Diabetes Care. 2004;27(12):2790-2796. doi:10.2337/diacare.27.12.2790
Rami-Merhar B, Hofer SE, Fröhlich-Reiterer E, Waldhoer T, Fritsch M. Time trends in incidence of diabetes mellitus in Austrian children and adolescents <15 years (1989-2017). Pediatr Diabetes. 2020;21(5):720-726. doi:10.1111/pedi.13038
Rahmati M, Keshvari M, Mirnasuri S, et al. The global impact of COVID-19 pandemic on the incidence of pediatric new-onset type 1 diabetes and ketoacidosis: a systematic review and meta-analysis. J Med Virol. 2022;94(11):5112-5127. doi:10.1002/jmv.27996
Wang K, Ye F, Chen Y, et al. Association between enterovirus infection and type 1 diabetes risk: a meta-analysis of 38 case-control studies. Front Endocrinol (Lausanne). 2021;12(September):1-9. doi:10.3389/fendo.2021.706964
Haynes A, Bulsara MK, Bower C, Jones TW, Davis EA. Cyclical variation in the incidence of childhood type 1 diabetes in Western Australia (1985-2010). Diabetes Care. 2012;35(11):2300-2302. doi:10.2337/dc12-0205