Titin activates myosin filaments in skeletal muscle by switching from an extensible spring to a mechanical rectifier.
muscle regulation
myosin filament activation
skeletal muscle
striated muscle
titin
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
28 02 2023
28 02 2023
Historique:
entrez:
22
2
2023
pubmed:
23
2
2023
medline:
25
2
2023
Statut:
ppublish
Résumé
Titin is a molecular spring in parallel with myosin motors in each muscle half-sarcomere, responsible for passive force development at sarcomere length (SL) above the physiological range (>2.7 μm). The role of titin at physiological SL is unclear and is investigated here in single intact muscle cells of the frog (
Identifiants
pubmed: 36812205
doi: 10.1073/pnas.2219346120
pmc: PMC9992839
doi:
Substances chimiques
Connectin
0
Myosins
EC 3.6.4.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2219346120Subventions
Organisme : Fondazione Cassa di Risparmio di Firenze (Fondazione CR Firenze)
ID : 2020-1660
Organisme : Università degli Studi di Firenze (UniFI)
ID : rictd 1819
Organisme : E-Rare (ERA-Net for Research Programmes on Rare Diseases)
ID : IDOLS-G 2019
Références
J Cell Biol. 1988 May;106(5):1563-72
pubmed: 2453516
J Mol Biol. 2020 Aug 7;432(17):4815-4829
pubmed: 32619437
J Gen Physiol. 2021 Jul 5;153(7):
pubmed: 33836065
Nature. 2005 Aug 25;436(7054):1195-9
pubmed: 16121187
J Gen Physiol. 2021 Jul 5;153(7):
pubmed: 34152365
J Mol Biol. 2003 Aug 15;331(3):713-24
pubmed: 12899839
J Cell Sci. 2004 Nov 15;117(Pt 24):5781-9
pubmed: 15507486
Annu Rev Physiol. 2018 Feb 10;80:389-411
pubmed: 29131758
Proteins. 2001 May 1;43(2):145-9
pubmed: 11276084
Science. 1985 Dec 13;230(4731):1280-2
pubmed: 4071053
J Muscle Res Cell Motil. 2012 Mar;32(6):403-9
pubmed: 22072314
Biophys J. 1995 Mar;68(3):1027-44
pubmed: 7756523
J Mol Biol. 2021 Apr 30;433(9):166901
pubmed: 33647290
J Biochem. 1988 Oct;104(4):504-8
pubmed: 3071530
J Exp Biol. 2018 Nov 16;221(Pt 22):
pubmed: 30237238
J Gen Physiol. 2021 Mar 1;153(3):
pubmed: 33416833
J Mol Biol. 1989 Jan 5;205(1):263-8
pubmed: 2926807
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7236-40
pubmed: 21482782
Biophys J. 1993 Nov;65(5):2141-59
pubmed: 8298040
J Muscle Res Cell Motil. 2019 Mar;40(1):29-41
pubmed: 30900059
Sci Rep. 2018 Oct 1;8(1):14575
pubmed: 30275509
Biophys J. 2019 Mar 19;116(6):983-984
pubmed: 30837077
J Mol Cell Cardiol. 2019 Aug;133:47-56
pubmed: 31158359
Am J Physiol Cell Physiol. 2016 Jan 1;310(1):C19-26
pubmed: 26405100
Biophys Physicobiol. 2018 Apr 27;15:111-120
pubmed: 29892517
Science. 1997 May 16;276(5315):1112-6
pubmed: 9148805
Biophys J. 2002 Jun;82(6):3118-27
pubmed: 12023235
Prog Biophys Mol Biol. 2012 Oct-Nov;110(2-3):204-17
pubmed: 22910434
J Cell Biol. 1998 Feb 23;140(4):853-9
pubmed: 9472037
Nat Rev Cardiol. 2013 Sep;10(9):531-47
pubmed: 23900355
Nature. 2004 Apr 1;428(6982):578-81
pubmed: 15058307
J Physiol. 2020 Jan;598(2):331-345
pubmed: 31786814
J Physiol. 1990 Dec;431:141-71
pubmed: 2100305
Int J Mol Sci. 2018 Sep 06;19(9):
pubmed: 30200618
J Muscle Res Cell Motil. 2003;24(2-3):175-89
pubmed: 14609029
J Struct Biol. 1997 Oct;120(1):93-104
pubmed: 9356297
Circulation. 2013 Feb 26;127(8):938-44
pubmed: 23439446
Am J Physiol Cell Physiol. 2014 Dec 15;307(12):C1123-9
pubmed: 25298425
Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C566-74
pubmed: 22094333
Biophys J. 2001 Oct;81(4):2297-313
pubmed: 11566799
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13716-21
pubmed: 14593205
Proc Natl Acad Sci U S A. 1979 Aug;76(8):3698-702
pubmed: 291034
J Appl Crystallogr. 2018 Oct 11;51(Pt 6):1511-1524
pubmed: 30546286
Prog Biophys Mol Biol. 1998;69(2-3):425-43
pubmed: 9785949
J Mol Biol. 1996 Aug 9;261(1):62-71
pubmed: 8760502
Nature. 2015 Dec 10;528(7581):276-9
pubmed: 26560032
Biochem Biophys Res Commun. 1996 Apr 25;221(3):491-7
pubmed: 8629989
J Gen Physiol. 2019 Jan 7;151(1):53-65
pubmed: 30510036
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8052-7
pubmed: 9653138
J Physiol. 1966 May;184(1):170-92
pubmed: 5921536
J Cell Sci. 1991 Dec;100 ( Pt 4):809-14
pubmed: 1726102
J Cell Sci. 1998 Jun;111 ( Pt 11):1567-74
pubmed: 9580564
Circ Res. 2000 Jun 9;86(11):1114-21
pubmed: 10850961
Nat Commun. 2017 Oct 19;8(1):1041
pubmed: 29051486
J Physiol. 2014 Mar 1;592(5):1119-37
pubmed: 24344169
Circ Res. 2001 Nov 9;89(10):874-81
pubmed: 11701614
Science. 1995 Oct 13;270(5234):293-6
pubmed: 7569978
Front Physiol. 2019 Nov 28;10:1436
pubmed: 31849696
J Biochem. 1977 Aug;82(2):347-50
pubmed: 914785
Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7226-31
pubmed: 10860988
J Mol Biol. 2008 Dec 5;384(1):60-72
pubmed: 18817784
Nat Commun. 2016 Oct 31;7:13281
pubmed: 27796302
J Mol Biol. 2001 Jan 19;305(3):401-9
pubmed: 11152599
Front Physiol. 2018 Jun 14;9:736
pubmed: 29962967
Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8211-5
pubmed: 24954740
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11423-8
pubmed: 21705660