Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
09 03 2023
09 03 2023
Historique:
pubmed:
23
2
2023
medline:
11
3
2023
entrez:
22
2
2023
Statut:
ppublish
Résumé
There is an urgent need to populate the antimalarial clinical portfolio with new candidates because of resistance against frontline antimalarials. To discover new antimalarial chemotypes, we performed a high-throughput screen of the Janssen Jumpstarter library against the
Identifiants
pubmed: 36812492
doi: 10.1021/acs.jmedchem.2c02092
pmc: PMC10009754
doi:
Substances chimiques
Antimalarials
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3540-3565Références
Clin Infect Dis. 2022 May 30;74(10):1831-1839
pubmed: 34410358
Clin Microbiol Infect. 2015 Jul;21(7):640-8
pubmed: 25843504
ACS Chem Biol. 2015 Feb 20;10(2):413-20
pubmed: 25322084
N Engl J Med. 2009 Jul 30;361(5):455-67
pubmed: 19641202
Sci Transl Med. 2015 Jul 15;7(296):296ra111
pubmed: 26180101
Acta Crystallogr D Struct Biol. 2018 Feb 1;74(Pt 2):106-116
pubmed: 29533236
J Biol Chem. 1999 Nov 19;274(47):33213-9
pubmed: 10559194
Cell Host Microbe. 2020 Apr 8;27(4):642-658.e12
pubmed: 32109369
Am J Trop Med Hyg. 2001 Jan-Feb;64(1-2 Suppl):97-106
pubmed: 11425182
Lancet Infect Dis. 2017 Jun;17(6):636-644
pubmed: 28363637
Org Lett. 2018 Jul 20;20(14):4218-4222
pubmed: 29956545
Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5455-62
pubmed: 25453091
J Med Chem. 2017 Feb 9;60(3):1171-1188
pubmed: 28080063
Sci Rep. 2018 Jun 11;8(1):8795
pubmed: 29892073
Bioorg Chem. 2021 Oct;115:105244
pubmed: 34452759
Trends Parasitol. 2021 Aug;37(8):709-721
pubmed: 34001441
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1128-36
pubmed: 22065754
Nat Med. 2020 Oct;26(10):1602-1608
pubmed: 32747827
Trends Parasitol. 2016 Oct;32(10):808-819
pubmed: 27480365
mBio. 2022 Oct 26;13(5):e0117822
pubmed: 36190127
Nat Commun. 2014 Nov 25;5:5521
pubmed: 25422853
Nat Commun. 2018 Sep 18;9(1):3805
pubmed: 30228275
Eur J Med Chem. 2018 Jun 25;154:182-198
pubmed: 29800827
Antimicrob Agents Chemother. 2012 Jul;56(7):3544-8
pubmed: 22508309
Biochem Pharmacol. 2010 May 1;79(9):1291-9
pubmed: 20067768
Malar J. 2017 Jan 13;16(1):26
pubmed: 28086874
ChemMedChem. 2022 Sep 16;17(18):e202200306
pubmed: 35906744
N Engl J Med. 2014 Jul 31;371(5):403-10
pubmed: 25075833
Infect Dis Poverty. 2019 Feb 13;8(1):14
pubmed: 30760324
Antimicrob Agents Chemother. 2018 May 25;62(6):
pubmed: 29555632
Cell Host Microbe. 2013 Feb 13;13(2):227-37
pubmed: 23414762
Nat Commun. 2016 Mar 01;7:10727
pubmed: 26925876
Lancet Infect Dis. 2017 Jun;17(6):626-635
pubmed: 28363636
J Med Chem. 2019 Dec 12;62(23):10526-10562
pubmed: 31385706
Nat Protoc. 2016 Sep;11(9):1668-80
pubmed: 27560172
Malar J. 2012 Aug 22;11:292
pubmed: 22913649
Nat Commun. 2022 Sep 30;13(1):5746
pubmed: 36180431
Fly (Austin). 2012 Apr-Jun;6(2):80-92
pubmed: 22728672
Acta Crystallogr A Found Adv. 2015 Jan;71(Pt 1):59-75
pubmed: 25537389
Mol Biochem Parasitol. 2004 Sep;137(1):23-33
pubmed: 15279948
Antimicrob Agents Chemother. 2019 Feb 26;63(3):
pubmed: 30559138
N Engl J Med. 2014 Jul 31;371(5):411-23
pubmed: 25075834
Infez Med. 2012 Mar;20(1):5-11
pubmed: 22475654
Mol Microbiol. 2014 Oct;94(2):327-39
pubmed: 25145582
Malar J. 2015 Nov 05;14:441
pubmed: 26542470
Science. 2010 Sep 3;329(5996):1175-80
pubmed: 20813948
EMBO J. 2006 Jun 7;25(11):2305-14
pubmed: 16710301
Am J Trop Med Hyg. 1993 Jun;48(6):739-41
pubmed: 8333566
Antimicrob Agents Chemother. 2014 Oct;58(10):6209-14
pubmed: 25114127