Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium.
lymphatic anatomy
lymphatic disease
lymphatic research
lymphedema
mapping
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2023
2023
Historique:
received:
15
11
2022
accepted:
20
01
2023
entrez:
23
2
2023
pubmed:
24
2
2023
medline:
24
2
2023
Statut:
epublish
Résumé
Enhancing our understanding of lymphatic anatomy from the microscopic to the anatomical scale is essential to discern how the structure and function of the lymphatic system interacts with different tissues and organs within the body and contributes to health and disease. The knowledge of molecular aspects of the lymphatic network is fundamental to understand the mechanisms of disease progression and prevention. Recent advances in mapping components of the lymphatic system using state of the art single cell technologies, the identification of novel biomarkers, new clinical imaging efforts, and computational tools which attempt to identify connections between these diverse technologies hold the potential to catalyze new strategies to address lymphatic diseases such as lymphedema and lipedema. This manuscript summarizes current knowledge of the lymphatic system and identifies prevailing challenges and opportunities to advance the field of lymphatic research as discussed by the experts in the workshop.
Identifiants
pubmed: 36814475
doi: 10.3389/fphys.2023.1099403
pii: 1099403
pmc: PMC9939837
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1099403Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL151388
Pays : United States
Informations de copyright
Copyright © 2023 Singhal, Börner, Chaikof, Detmar, Hollmén, Iliff, Itkin, Makinen, Oliver, Padera, Quardokus, Radtke, Suami, Weber, Rovira, Muratoglu and Galis.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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