White Matter Hyperintensities of the Corpus Callosum Are Associated With Clinical Severity in CADASIL.
CADASIL
corpus callosum
linear models
prospective studies
white matter hyperintensities
Journal
Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
medline:
29
3
2023
pubmed:
24
2
2023
entrez:
23
2
2023
Statut:
ppublish
Résumé
In CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy), clinical severity is not related to the total burden of white matter hyperintensities (WMHs), presumably because of heterogeneous underlying tissue alterations. We aimed to investigate whether WMHs in the corpus callosum (WMH We evaluated data from 228 CADASIL patients included in an ongoing prospective cohort with available 3-dimensional fluid-attenuated inversion recovery magnetic resonance imaging sequences. We analyzed in a blind manner WMH Among 228 patients, only 105 (46%) had WMH In CADASIL, WMH
Sections du résumé
BACKGROUND
In CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy), clinical severity is not related to the total burden of white matter hyperintensities (WMHs), presumably because of heterogeneous underlying tissue alterations. We aimed to investigate whether WMHs in the corpus callosum (WMH
METHODS
We evaluated data from 228 CADASIL patients included in an ongoing prospective cohort with available 3-dimensional fluid-attenuated inversion recovery magnetic resonance imaging sequences. We analyzed in a blind manner WMH
RESULTS
Among 228 patients, only 105 (46%) had WMH
CONCLUSIONS
In CADASIL, WMH
Identifiants
pubmed: 36815459
doi: 10.1161/STROKEAHA.122.040938
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM