Genetic analysis of suicide: a sample study in Tuscany (Central Italy).
Forensic sciences
HTR2A
MAOA
NOS3
SCN8A
forensic genetics
suicide
Journal
Forensic sciences research
ISSN: 2471-1411
Titre abrégé: Forensic Sci Res
Pays: England
ID NLM: 101724928
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
23
2
2023
pubmed:
24
2
2023
medline:
24
2
2023
Statut:
epublish
Résumé
Many studies have examined the genetic contribution to suicide. However, data on suicide in the Italian population are scarce. We therefore aimed to address this gap by investigating a cohort of 111 Italians for whom a verdict of suicide had been declared in court in Florence, Italy between 2007 and 2017. This cohort included 86 men and 25 women. DNA samples were obtained from tissues or blood, and 22 genes from multiple neurobiological pathways previously shown to be associated with the pathogenesis of suicide were analysed. Next-generation sequencing was used to compare these gene sequences with those from a large, normal population. In this study, we identified 19 gene variants that were present at significantly lower frequencies in our Italian cohort than in the general population. In addition, four missense mutations were identified in four different genes: Monoamine Oxidase A (
Identifiants
pubmed: 36817247
doi: 10.1080/20961790.2020.1835156
pii: 1835156
pmc: PMC9930793
doi:
Types de publication
Case Reports
Langues
eng
Pagination
790-797Informations de copyright
© 2022 The Author(s). Published by Taylor & Francis Group on behalf of the Academy of Forensic Science.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest.
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