Mechanical Evaluation of Hydrogel-Elastomer Interfaces Generated through Thiol-Ene Coupling.
Journal
ACS applied polymer materials
ISSN: 2637-6105
Titre abrégé: ACS Appl Polym Mater
Pays: United States
ID NLM: 101734999
Informations de publication
Date de publication:
10 Feb 2023
10 Feb 2023
Historique:
received:
27
10
2022
accepted:
06
01
2023
entrez:
23
2
2023
pubmed:
24
2
2023
medline:
24
2
2023
Statut:
epublish
Résumé
The formation of hybrid hydrogel-elastomer scaffolds is an attractive strategy for the formation of tissue engineering constructs and microfabricated platforms for advanced in vitro models. The emergence of thiol-ene coupling, in particular radical-based, for the engineering of cell-instructive hydrogels and the design of elastomers raises the possibility of mechanically integrating these structures without relying on the introduction of additional chemical moieties. However, the bonding of hydrogels (thiol-ene radical or more classic acrylate/methacrylate radical-based) to thiol-ene elastomers and alkene-functional elastomers has not been characterized in detail. In this study, we quantify the tensile mechanical properties of hybrid hydrogel samples formed of two elastomers bonded to a hydrogel material. We examine the impact of radical thiol-ene coupling on the crosslinking of both elastomers (silicone or polyesters) and hydrogels (based on thiol-ene crosslinking or diacrylate chemistry) and on the mechanics and failure behavior of the resulting hybrids. This study demonstrates the strong bonding of thiol-ene hydrogels to alkene-presenting elastomers with a range of chemistries, including silicones and polyesters. Overall, thiol-ene coupling appears as an attractive tool for the generation of strong, mechanically integrated, hybrid structures for a broad range of applications.
Identifiants
pubmed: 36817337
doi: 10.1021/acsapm.2c01878
pmc: PMC9926487
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1364-1373Informations de copyright
© 2023 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
J Mater Chem B. 2013 Jan 14;1(2):221-229
pubmed: 32260695
Biomaterials. 2012 Jan;33(1):48-58
pubmed: 21955690
Lab Chip. 2011 Sep 21;11(18):3136-47
pubmed: 21804987
Nat Mater. 2021 Apr;20(4):560-569
pubmed: 33168979
Biomaterials. 2011 May;32(14):3564-74
pubmed: 21334063
Biomaterials. 2021 Feb;269:120356
pubmed: 33189358
Biotechnol Prog. 2022 May;38(3):e3234
pubmed: 35037419
Chem Rev. 2009 Nov;109(11):5620-86
pubmed: 19905010
Nat Mater. 2013 May;12(5):458-65
pubmed: 23524375
Science. 2010 Jun 25;328(5986):1662-8
pubmed: 20576885
Acta Biomater. 2022 Mar 1;140:700-716
pubmed: 34954418
Angew Chem Int Ed Engl. 2010 Feb 22;49(9):1540-73
pubmed: 20166107
Acta Biomater. 2013 Aug;9(8):7709-18
pubmed: 23603533
Biomacromolecules. 2014 Nov 10;15(11):4351-62
pubmed: 25322257
Biomacromolecules. 2020 Jun 8;21(6):1968-1994
pubmed: 32227919
Int J Pharm. 2022 Jun 25;622:121828
pubmed: 35595041
Biomater Sci. 2014 Nov 30;2(11):1612-1626
pubmed: 25717375
Acta Biomater. 2016 Apr 01;34:113-124
pubmed: 26646540
Cell Rep. 2017 Oct 10;21(2):508-516
pubmed: 29020635
ACS Appl Mater Interfaces. 2019 Apr 17;11(15):14391-14398
pubmed: 30912634
Front Bioeng Biotechnol. 2022 Jul 19;10:915702
pubmed: 35928950
Nat Methods. 2016 Apr 28;13(5):405-14
pubmed: 27123816
Biomater Sci. 2021 Feb 7;9(3):535-573
pubmed: 33185203
Nano Lett. 2015 Jul 8;15(7):4720-9
pubmed: 26027605
Bioconjug Chem. 2016 Sep 21;27(9):2111-23
pubmed: 27510221
J Cell Sci. 2012 Aug 15;125(Pt 16):3765-75
pubmed: 22553208
Nat Commun. 2018 Feb 28;9(1):878
pubmed: 29491371
Adv Ther (Weinh). 2022 Aug;5(8):
pubmed: 36589207
Chem Soc Rev. 2017 Oct 30;46(21):6532-6552
pubmed: 28820527
Biomaterials. 2010 Nov;31(32):8228-34
pubmed: 20674004
ACS Appl Bio Mater. 2020 Sep 21;3(9):6497-6509
pubmed: 35021781
Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12132-12136
pubmed: 28799225
J Biomed Mater Res A. 2021 Dec;109(12):2425-2437
pubmed: 34033241
Nat Mater. 2019 Aug;18(8):883-891
pubmed: 30886401
J Control Release. 2015 Dec 10;219:95-106
pubmed: 26315818
ACS Appl Mater Interfaces. 2020 Mar 4;12(9):10080-10095
pubmed: 32048822
Biomacromolecules. 2012 Jul 9;13(7):2003-12
pubmed: 22708824
Adv Mater. 2011 Mar 25;23(12):H41-56
pubmed: 21394792
J Tissue Eng. 2020 Sep 1;11:2041731420942462
pubmed: 32944210
Biomacromolecules. 2016 Apr 11;17(4):1321-9
pubmed: 26902925
Soft Matter. 2021 Jul 7;17(26):6394-6403
pubmed: 34132302
Adv Sci (Weinh). 2022 Apr;9(12):e2105325
pubmed: 35187856
Lab Chip. 2018 Sep 11;18(18):2686-2709
pubmed: 30110034
Biomacromolecules. 2013 Oct 14;14(10):3626-34
pubmed: 24007393
J Biomed Mater Res B Appl Biomater. 2013 May;101(4):648-55
pubmed: 23359448
Science. 2016 Sep 16;353(6305):1264-8
pubmed: 27634530
ACS Appl Mater Interfaces. 2015 Dec 30;7(51):28673-81
pubmed: 26650346
ACS Biomater Sci Eng. 2016 Oct 10;2(10):1732-1742
pubmed: 33440471
J Mater Chem B. 2016 Jul 21;4(27):4707-4716
pubmed: 32263243