Diffusion-Weighted MRI in the Evaluation of Early-Stage Breast Cancer Treated with a Short Preoperative Radiotherapy: Preliminary Results.
Ki-67 index
apparent diffusion coefficient
diffusion-weighted MRI
early-stage breast cancer
neoadjuvant radiotherapy
Journal
Journal of the Belgian Society of Radiology
ISSN: 2514-8281
Titre abrégé: J Belg Soc Radiol
Pays: England
ID NLM: 101698198
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
03
2022
accepted:
30
12
2022
entrez:
23
2
2023
pubmed:
24
2
2023
medline:
24
2
2023
Statut:
epublish
Résumé
To assess tumor response with diffusion-weighted MRI (DW-MRI) after a short preoperative radiotherapy in early-stage breast cancer (BCa). This was a prospective, single-center pilot study. 3T-MRI were performed before and after radiotherapy. The longest diameter (LD) and the apparent diffusion coefficient (ADC) value of a region of interest (ROI) of the tumors were recorded. Histopathology and immunohistochemistry, including the Ki-67 index of the core biopsy and of the surgical specimen, were the reference standards. Nineteen patients with 22 early-stage BCa were included. The mean ROI ADC value was 1.093 ± 0.278 × 10 In early-stage BCa, a significant increase in ROI-ADC at DWI and a significant decrease in Ki-67 index were observed after a short preoperative radiotherapy, suggesting early tumor response.
Identifiants
pubmed: 36817566
doi: 10.5334/jbsr.2815
pmc: PMC9912849
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8Informations de copyright
Copyright: © 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors have no competing interests to declare.
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