Exome-wide analysis identify multiple variations in olfactory receptor genes (

Saudi females autism spectrum disorder coding variants haplotyping single nucleotide polymorphism

Journal

Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047

Informations de publication

Date de publication:
2023
Historique:
received: 22 09 2022
accepted: 13 01 2023
entrez: 23 2 2023
pubmed: 24 2 2023
medline: 24 2 2023
Statut: epublish

Résumé

Autism Spectrum Disorder (ASD) is a multifactorial, neurodevelopmental disorder, characterized by deficits in communication, restricted and repetitive behaviors. ASD is highly heritable in Saudi Arabia; indecencies of affected individuals are increasing. To identify the most significant genes and SNPs associated with the increased risk of ASD in Saudi females to give an insight for early diagnosis. Pilot case-control study mostly emphasized on the significant SNPs and haplotypes contributing to Saudi females with ASD patients ( In females, five risk SNPs at Multiple variations in olfactory receptor genes (

Sections du résumé

Background UNASSIGNED
Autism Spectrum Disorder (ASD) is a multifactorial, neurodevelopmental disorder, characterized by deficits in communication, restricted and repetitive behaviors. ASD is highly heritable in Saudi Arabia; indecencies of affected individuals are increasing.
Objectives UNASSIGNED
To identify the most significant genes and SNPs associated with the increased risk of ASD in Saudi females to give an insight for early diagnosis.
Methods UNASSIGNED
Pilot case-control study mostly emphasized on the significant SNPs and haplotypes contributing to Saudi females with ASD patients (
Results UNASSIGNED
In females, five risk SNPs at
Conclusion UNASSIGNED
Multiple variations in olfactory receptor genes (

Identifiants

pubmed: 36817779
doi: 10.3389/fmed.2023.1051039
pmc: PMC9928728
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1051039

Informations de copyright

Copyright © 2023 Almandil, Alismail, Alsuwat, AlSulaiman, AbdulAzeez and Borgio.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Noor B Almandil (NB)

Department of Clinical Pharmacy Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Maram Adnan Alismail (MA)

Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Hind Saleh Alsuwat (HS)

Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Abdulla AlSulaiman (A)

Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Sayed AbdulAzeez (S)

Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

J Francis Borgio (JF)

Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Classifications MeSH