Nanoscale metal-organic frameworks for the delivery of nucleic acids to cancer cells.
Drug incorporation
Intracellular drug delivery
Nanoscale metal-organic frameworks
Surface engineering
Therapeutic nucleic acids
Journal
International journal of pharmaceutics: X
ISSN: 2590-1567
Titre abrégé: Int J Pharm X
Pays: Netherlands
ID NLM: 101753452
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
07
01
2023
accepted:
07
01
2023
entrez:
23
2
2023
pubmed:
24
2
2023
medline:
24
2
2023
Statut:
epublish
Résumé
Therapeutic nucleic acids (TNAs) are gaining increasing interest in the treatment of severe diseases including viral infections, inherited disorders, and cancers. However, the efficacy of intracellularly functioning TNAs is also reliant upon their delivery into the cellular environment, as unmodified nucleic acids are unable to cross the cell membrane mainly due to charge repulsion. Here we show that TNAs can be effectively delivered into the cellular environment using engineered nanoscale metal-organic frameworks (nanoMOFs), with the additional ability to tailor which cells receive the therapeutic cargo determined by the functional moieties grafted onto the nanoMOF's surface. This study paves the way to integrate the highly ordered programmable nucleic acids into larger-scale functionalized nanoassemblies.
Identifiants
pubmed: 36817971
doi: 10.1016/j.ijpx.2023.100161
pii: S2590-1567(23)00005-1
pmc: PMC9931914
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100161Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM139587
Pays : United States
Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
None.
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