Angiopoietin-1 derived peptide hydrogel promotes molecular hallmarks of regeneration and wound healing in dermal fibroblasts.

Biomaterials Health sciences Materials science

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
17 Feb 2023
Historique:
received: 18 02 2022
revised: 12 10 2022
accepted: 11 01 2023
entrez: 23 2 2023
pubmed: 24 2 2023
medline: 24 2 2023
Statut: epublish

Résumé

By providing an ideal environment for healing, biomaterials can be designed to facilitate and encourage wound regeneration. As the wound healing process is complex, there needs to be consideration for the cell types playing major roles, such as fibroblasts. As a major cell type in the dermis, fibroblasts have a large impact on the processes and outcomes of wound healing. Prevopisly, conjugating the angiopoietin-1 derived Q-peptide (QHREDGS) to a collagen-chitosan hydrogel created a biomaterial with

Identifiants

pubmed: 36818306
doi: 10.1016/j.isci.2023.105984
pii: S2589-0042(23)00061-5
pmc: PMC9932487
doi:

Types de publication

Journal Article

Langues

eng

Pagination

105984

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

M.R. is a founder of Quthero Inc, holds equity in the company, receives consulting fees from the company and is a member of its Board of Directors. S.M. holds equity in Quthero Inc. M.R. and S.M. are inventors of patents licensed by Quthero Inc and they receive royalty payments from those patents.

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Auteurs

Katrina Vizely (K)

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.

Karl T Wagner (KT)

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.

Serena Mandla (S)

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.

Dakota Gustafson (D)

Toronto General Hospital Research Institute, University Health Network, Toronto,ON M5G 2C4, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Jason E Fish (JE)

Toronto General Hospital Research Institute, University Health Network, Toronto,ON M5G 2C4, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Milica Radisic (M)

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Toronto General Hospital Research Institute, University Health Network, Toronto,ON M5G 2C4, Canada.

Classifications MeSH