Association of the risk factor
UNC13A
alleles
amyotrophic lateral sclerosis
behavioral symptoms
genotype
motor neurons
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2023
2023
Historique:
received:
12
10
2022
accepted:
03
01
2023
entrez:
23
2
2023
pubmed:
24
2
2023
medline:
24
2
2023
Statut:
epublish
Résumé
The Genotype data of the The rs12608932 minor allele frequency was 0.31 in our ALS cohort, in comparison to 0.33-0.41 reported in other Caucasian ALS populations. Carriers of at least one minor C allele (AC + CC genotypes) had a shorter median survival than patients with the wild-type AA genotype (-11.7 months, Overall, our findings confirm the role of
Sections du résumé
Background
UNASSIGNED
The
Methods
UNASSIGNED
Genotype data of the
Results
UNASSIGNED
The rs12608932 minor allele frequency was 0.31 in our ALS cohort, in comparison to 0.33-0.41 reported in other Caucasian ALS populations. Carriers of at least one minor C allele (AC + CC genotypes) had a shorter median survival than patients with the wild-type AA genotype (-11.7 months,
Conclusion
UNASSIGNED
Overall, our findings confirm the role of
Identifiants
pubmed: 36819716
doi: 10.3389/fnagi.2023.1067954
pmc: PMC9931189
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1067954Informations de copyright
Copyright © 2023 Manini, Casiraghi, Brusati, Maranzano, Gentile, Colombo, Bonetti, Peverelli, Invernizzi, Gentilini, Messina, Verde, Poletti, Fogh, Morelli, Silani, Ratti and Ticozzi.
Déclaration de conflit d'intérêts
VS received compensation for consulting services and/or speaking activities from AveXis, Cytokinetics, Italfarmaco, Liquidweb Srl, Novartis Pharma AG, and Zambon. He is on the Editorial Board of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, European Neurology, American Journal of Neurodegenerative Diseases, Frontiers in Neurology, and Exploration of Neuroprotective Therapy. FV and CM are Review Editor of Frontiers in Aging Neuroscience. BP received compensation for consulting services and/or speaking activities from Liquidweb S.r.l. She is Associate Editor for Frontiers in Neuroscience. NT received compensation for consulting services from Amylyx Pharmaceuticals and Zambon Biotech SA. He is Associate Editor for Frontiers in Aging Neuroscience. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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