Impact of phenotypic rapid diagnostic assay on duration of empiric antibiotics for gram-negative bacteremia.
Journal
Antimicrobial stewardship & healthcare epidemiology : ASHE
ISSN: 2732-494X
Titre abrégé: Antimicrob Steward Healthc Epidemiol
Pays: England
ID NLM: 9918266096106676
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
08
2022
revised:
14
10
2022
accepted:
17
10
2022
entrez:
23
2
2023
pubmed:
24
2
2023
medline:
24
2
2023
Statut:
epublish
Résumé
Rapid diagnostic tests (RDTs) are increasingly being implemented as antimicrobial stewardship tools to facilitate antibiotic modification and reduce complications related to their overutilization. We measured the clinical impact of a phenotypic RDT with antimicrobial stewardship (AMS) in the setting of gram-negative bacteremia. In this single-center retrospective cohort study, we evaluated adult patients with gram-negative bacteremia who received at least 72 hours of an antibiotic. The primary outcome was the duration of empiric antibiotic therapy for gram-negative bacteremia. Secondary outcomes included time-to-directed therapy, proportion of modifications, hospital length of stay (LOS), and subsequent infection with a multidrug-resistant organism (MDRO) or The duration of empiric antibiotics decreased in the RDT+AMS group (4 days vs 2 days; The clinical outcomes of LOS, MDRO, and CDI were reduced. The phenotypic RDT demonstrated an improvement in stewardship measures and clinical outcomes.
Identifiants
pubmed: 36819771
doi: 10.1017/ash.2022.331
pii: S2732494X2200331X
pmc: PMC9936510
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e22Informations de copyright
© The Author(s) 2023.
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