Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells.
Journal
Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951
Informations de publication
Date de publication:
15 Feb 2023
15 Feb 2023
Historique:
received:
25
07
2022
accepted:
02
01
2023
entrez:
23
2
2023
pubmed:
24
2
2023
medline:
24
2
2023
Statut:
epublish
Résumé
The COVID-19 pandemic has revealed the vulnerability of the modern, global society. With expected waves of future infections by SARS-CoV-2, treatment options for infected individuals will be crucial in order to decrease mortality and hospitalizations. The SARS-CoV-2 main protease is a validated drug target, for which the first inhibitor has been approved for use in patients. To facilitate future work on this drug target, we designed a solid-phase synthesis route towards azapeptide activity-based probes that are capped with a cysteine-reactive electrophile for covalent modification of the active site of M
Identifiants
pubmed: 36819852
doi: 10.1039/d2sc04147b
pii: d2sc04147b
pmc: PMC9931053
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1666-1672Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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