Air pollution and decreased bone mineral density among Women's Health Initiative participants.
Air pollution
Bone damage
Bone mineral density
Mixtures
Postmenopause
Journal
EClinicalMedicine
ISSN: 2589-5370
Titre abrégé: EClinicalMedicine
Pays: England
ID NLM: 101733727
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
31
10
2022
revised:
25
01
2023
accepted:
26
01
2023
entrez:
23
2
2023
pubmed:
24
2
2023
medline:
24
2
2023
Statut:
epublish
Résumé
Osteoporosis heavily affects postmenopausal women and is influenced by environmental exposures. Determining the impact of criteria air pollutants and their mixtures on bone mineral density (BMD) in postmenopausal women is an urgent priority. We conducted a prospective observational study using data from the ethnically diverse Women's Health Initiative Study (WHI) (enrollment, September 1994-December 1998; data analysis, January 2020 to August 2022). We used log-normal, ordinary kriging to estimate daily mean concentrations of PM In cross-sectional and longitudinal analyses, mean PM In this cohort study, higher levels of air pollutants were associated with bone damage, particularly on lumbar spine, among postmenopausal women. These findings highlight nitrogen oxides exposure as a leading contributor to bone loss in postmenopausal women, expanding previous findings of air pollution-related bone damage. US National Institutes of Health.
Sections du résumé
Background
UNASSIGNED
Osteoporosis heavily affects postmenopausal women and is influenced by environmental exposures. Determining the impact of criteria air pollutants and their mixtures on bone mineral density (BMD) in postmenopausal women is an urgent priority.
Methods
UNASSIGNED
We conducted a prospective observational study using data from the ethnically diverse Women's Health Initiative Study (WHI) (enrollment, September 1994-December 1998; data analysis, January 2020 to August 2022). We used log-normal, ordinary kriging to estimate daily mean concentrations of PM
Findings
UNASSIGNED
In cross-sectional and longitudinal analyses, mean PM
Interpretation
UNASSIGNED
In this cohort study, higher levels of air pollutants were associated with bone damage, particularly on lumbar spine, among postmenopausal women. These findings highlight nitrogen oxides exposure as a leading contributor to bone loss in postmenopausal women, expanding previous findings of air pollution-related bone damage.
Funding
UNASSIGNED
US National Institutes of Health.
Identifiants
pubmed: 36820096
doi: 10.1016/j.eclinm.2023.101864
pii: S2589-5370(23)00041-X
pmc: PMC9938170
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101864Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
Most authors declare that they have no competing interest in any form. JWW declares funding from NHLBI/NIH to support the Women's Health Initiative (JWW is the PI of the northeast WHI regional center), which has occurred since 1993 and will go through 2027. WHI funding for JWW supports support travel to the annual WHI meeting. JWW is dean of the School of Public Health and Health Professions at the University at Buffalo and serves as a board member of several western New York community organizations (unpaid). GM receives royalties for his books (The exposome: a primer [2014]; The exposome: a new paradigm for health and disease [2020], published by Academic Press). GM also receives stipend for serving as Editor of Exposome, published by Oxford University Press. GM also has received honoraria from Kansas University Medical Center (speaker), Mayo Clinic (speaker), Foundation for Gender Specific Medicine (book chapter), AAAS (speaker), Vichy (speaker), University of Colorado (speaker), and the University of Arizona (speaker). When GM speaks at universities in the U.S. the travel is paid by them.
Références
Environ Int. 2019 Nov;132:105077
pubmed: 31415963
PLoS Med. 2020 Aug 6;17(8):e1003188
pubmed: 32760064
N Engl J Med. 2006 Feb 16;354(7):669-83
pubmed: 16481635
Environ Res. 2009 Jul;109(5):528-35
pubmed: 19304283
PLoS One. 2019 May 29;14(5):e0217348
pubmed: 31141566
Chemosphere. 2023 Jan;310:136871
pubmed: 36244420
JAMA. 2005 May 11;293(18):2257-64
pubmed: 15886381
Circ Res. 2016 Nov 11;119(11):1204-1214
pubmed: 27780829
J Bone Miner Res. 2003 Feb;18(2):343-51
pubmed: 12568412
Environ Health Perspect. 2010 May;118(5):673-8
pubmed: 20075021
Environ Health Perspect. 1998 Sep;106(9):535-49
pubmed: 9721253
Front Cell Neurosci. 2018 Apr 27;12:114
pubmed: 29755324
Arh Hig Rada Toksikol. 2013;64(1):23-34
pubmed: 23612523
JAMA Netw Open. 2020 Jan 3;3(1):e1918504
pubmed: 31899531
Epidemiology. 2014 Jan;25(1):35-43
pubmed: 24220191
Environ Health Perspect. 2000 May;108(5):419-26
pubmed: 10811568
Biostatistics. 2015 Jul;16(3):493-508
pubmed: 25532525
CA Cancer J Clin. 2020 Aug 25;:
pubmed: 32964460
Nutr Res. 2011 Jan;31(1):48-54
pubmed: 21310306
N Engl J Med. 2001 Jul 12;345(2):99-106
pubmed: 11450679
Control Clin Trials. 1998 Feb;19(1):61-109
pubmed: 9492970
Environ Health Perspect. 2006 Sep;114(9):1374-80
pubmed: 16966091
Osteoporos Int. 2017 Dec;28(12):3301-3314
pubmed: 28916915
Environ Health. 2014 Aug 05;13:63
pubmed: 25097007
Ann Epidemiol. 2003 Oct;13(9 Suppl):S98-106
pubmed: 14575942
J Bone Miner Metab. 2020 Nov;38(6):839-847
pubmed: 32507945
Int J Environ Res Public Health. 2020 Dec 08;17(24):
pubmed: 33302461
Am J Respir Crit Care Med. 2001 Sep 1;164(5):826-30
pubmed: 11549540
Neurochem Int. 2020 Jun;136:104708
pubmed: 32092328
Risk Manag Healthc Policy. 2021 Jun 24;14:2715-2732
pubmed: 34194253
J Bone Miner Res. 2014 Jan;29(1):212-22
pubmed: 23775851
Occup Environ Med. 1998 Oct;55(10):651-6
pubmed: 9930084
Scand J Gastroenterol. 2020 Mar;55(3):272-278
pubmed: 32064969
Environ Health Perspect. 2017 Jan;125(1):38-46
pubmed: 27340825
J Occup Environ Med. 2020 Dec;62(12):1034-1039
pubmed: 33065728
Osteoporos Int. 2018 Oct;29(10):2231-2241
pubmed: 30094608
J Am Geriatr Soc. 2003 Sep;51(9):1219-26
pubmed: 12919233
Int J Environ Res Public Health. 2018 Oct 01;15(10):
pubmed: 30275384
Osteoporos Int. 2022 Nov;33(11):2357-2368
pubmed: 35831465
BMJ. 2009 Jun 29;338:b2393
pubmed: 19564179
Osteoporos Int. 2022 Jan;33(1):169-176
pubmed: 34268604
Thorax. 2016 Oct;71(10):891-8
pubmed: 27491839
BMC Public Health. 2021 Oct 6;21(1):1794
pubmed: 34610796
Eur Heart J. 2019 May 21;40(20):1590-1596
pubmed: 30860255
Epidemiol Perspect Innov. 2006 Jul 20;3:8
pubmed: 16857050
Environ Int. 2018 Dec;121(Pt 2):1243-1252
pubmed: 30389378
Br Med Bull. 2020 May 15;133(1):105-117
pubmed: 32282039
Environ Sci Technol. 2001 Dec 1;35(23):4604-21
pubmed: 11770762
Mutat Res. 2009 Mar 31;674(1-2):45-54
pubmed: 19013537
J Bone Miner Res. 2007 Mar;22(3):465-75
pubmed: 17144789
Lancet Planet Health. 2017 Nov;1(8):e337-e347
pubmed: 29527596
Front Public Health. 2020 Feb 20;8:14
pubmed: 32154200
Best Pract Res Clin Endocrinol Metab. 2008 Oct;22(5):671-85
pubmed: 19028351
Int J Cardiol. 2018 Mar 15;255:231-236
pubmed: 29288056
Environ Health Perspect. 1996 Aug;104(8):838-50
pubmed: 8875158
Am J Epidemiol. 2004 Nov 15;160(10):1023-9
pubmed: 15522859
Air Qual Atmos Health. 2010 Nov 10;4(1):79-93
pubmed: 21461032
Stat Med. 2008 Jul 30;27(17):3227-46
pubmed: 18203127
Sci Rep. 2020 Oct 8;10(1):16845
pubmed: 33033284
Lancet. 1993 Aug 14;342(8868):418-21
pubmed: 8101908
Environ Anal Health Toxicol. 2020 Dec;35(4):e2020023-0
pubmed: 33434423
Int J Environ Res Public Health. 2021 Sep 13;18(18):
pubmed: 34574569
Environ Sci Pollut Res Int. 2022 Sep;29(41):62160-62207
pubmed: 34617231
Environ Res. 2022 Sep;212(Pt C):113360
pubmed: 35500859
Maturitas. 2019 Apr;122:51-56
pubmed: 30797530
Lancet Planet Health. 2021 Mar;5(3):e121-e134
pubmed: 33482109
Epidemiology. 2010 Mar;21(2):215-23
pubmed: 20087191
Am J Epidemiol. 1977 May;105(5):488-95
pubmed: 871121
Eur Respir J. 2011 Aug;38(2):303-9
pubmed: 21177840
Cell Death Differ. 2015 Mar;22(3):377-88
pubmed: 25257172
Environ Res. 2020 Apr;183:109264
pubmed: 32311909
Environ Health Perspect. 2017 Jun 26;125(6):067015
pubmed: 28669934
Physiol Rev. 2017 Jan;97(1):135-187
pubmed: 27807202
Osteoporos Int. 1996;6(4):320-4
pubmed: 8883122