Protection against severe COVID-19 after second booster dose of adapted bivalent (original/Omicron BA.4-5) mRNA vaccine in persons ≥ 60 years, by time since infection, Italy, 12 September to 11 December 2022.

COVID-19 Italy SARS-CoV-2 bivalent mRNA vaccines effectiveness elderly population

Journal

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
ISSN: 1560-7917
Titre abrégé: Euro Surveill
Pays: Sweden
ID NLM: 100887452

Informations de publication

Date de publication:
02 2023
Historique:
entrez: 23 2 2023
pubmed: 24 2 2023
medline: 3 3 2023
Statut: ppublish

Résumé

Effectiveness against severe COVID-19 of a second booster dose of the bivalent (original/BA.4-5) mRNA vaccine 7-90 days post-administration, relative to a first booster dose of an mRNA vaccine received ≥ 120 days earlier, was ca 60% both in persons ≥ 60 years never infected and in those infected > 6 months before. Relative effectiveness in those infected 4-6 months earlier indicated no significant additional protection (10%; 95% CI: -44 to 44). A second booster vaccination 6 months after the latest infection may be warranted.

Identifiants

pubmed: 36820640
doi: 10.2807/1560-7917.ES.2023.28.8.2300105
pmc: PMC9951255
doi:

Substances chimiques

RNA, Messenger 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

Lancet Infect Dis. 2023 Feb;23(2):167-176
pubmed: 36270311
Lancet Infect Dis. 2023 Feb;23(2):148-150
pubmed: 36620968
Lancet Infect Dis. 2023 Jan 18;:
pubmed: 36681084

Auteurs

Massimo Fabiani (M)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Alberto Mateo-Urdiales (A)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Chiara Sacco (C)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
European Programme on Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, Stockholm, Sweden.

Emmanouil Alexandros Fotakis (EA)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
European Programme on Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, Stockholm, Sweden.

Maria Cristina Rota (MC)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Daniele Petrone (D)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Marco Bressi (M)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Martina Del Manso (M)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Andrea Siddu (A)

General Directorate of Prevention, Italian Ministry of Health, Rome, Italy.

Giorgio Fedele (G)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Paola Stefanelli (P)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Antonino Bella (A)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Flavia Riccardo (F)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Anna Teresa Palamara (AT)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Giovanni Rezza (G)

General Directorate of Prevention, Italian Ministry of Health, Rome, Italy.

Silvio Brusaferro (S)

Office of the President, Istituto Superiore di Sanità, Rome, Italy.

Patrizio Pezzotti (P)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
The members of the group are listed under Acknowledgements.

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