Essential thrombocythemia manifesting as livedoid and purpuric skin lesions: Report of two cases and literature review.
Journal
Journal of cutaneous pathology
ISSN: 1600-0560
Titre abrégé: J Cutan Pathol
Pays: United States
ID NLM: 0425124
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
revised:
11
02
2023
received:
17
08
2022
accepted:
21
02
2023
medline:
14
7
2023
pubmed:
24
2
2023
entrez:
23
2
2023
Statut:
ppublish
Résumé
Essential thrombocythemia is a chronic myeloproliferative syndrome which usually runs its course as an asymptomatic elevated platelet count. Cutaneous manifestations secondary to microcirculation abnormalities are rare but can represent a helpful diagnostic clue in order to prevent major thromboembolic events. We report two cases of heterogeneous livedoid and "net-like" skin lesions in the context of essential thrombocythemia with identical histopathologic findings (medium-sized blood vessels with luminal obliteration by eosinophilic material, mostly positive for the platelet marker CD61, without vasculitis). In conclusion, we seek to raise awareness of the clinicopathological features of essential thrombocythemia to allow for prompt diagnosis and treatment.
Types de publication
Review
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
702-705Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
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Jensen MK, de Nully Brown P, Nielsen OJ, Hasselbalch HC. Incidence, clinical features and outcome of essential thrombocythaemia in a well defined geographical area. Eur J Haematol. 2000;65(2):132-139. doi:10.1034/j.1600-0609.2000.90236.x
Cozzani E, Iurlo A, Merlo G, et al. Essential thrombocythemia: the dermatologic point of view. Clin Lymphoma Myeloma Leuk. 2015;15(12):739-747. doi:10.1016/j.clml.2015.08.086
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Inoue S, Okiyama N, Okune M, Shiraki N, Kessoku R, Fujimoto M. Clinical and histological characteristics of livedo racemosa in essential thrombocythemia: a report of two cases and review of the published works. J Dermatol. 2017;44(1):84-87. doi:10.1111/1346-8138.13561