Phytochemicals and quaternary phosphonium ionic liquids: Connecting the dots to develop a new class of antimicrobial agents.

Humans Methicillin-Resistant Staphylococcus aureus Staphylococcus aureus Ionic Liquids / pharmacology Anti-Bacterial Agents / pharmacology Bacteria Escherichia coli
Antibiotics Antimicrobial resistance Bacterial membrane disruption Methicillin-resistant S. aureus Phytochemical-based TPP(+) conjugates

Journal

Journal of advanced research
ISSN: 2090-1224
Titre abrégé: J Adv Res
Pays: Egypt
ID NLM: 101546952

Informations de publication

Date de publication:
12 2023
Historique:
received: 28 11 2022
revised: 03 02 2023
accepted: 08 02 2023
medline: 4 12 2023
pubmed: 24 2 2023
entrez: 23 2 2023
Statut: ppublish

Résumé

The infections by multidrug-resistant bacteria are a growing threat to human health, and the efficacy of the available antibiotics is gradually decreasing. As such, new antibiotic classes are urgently needed. This study aims to evaluate the antimicrobial activity, safety and mechanism of action of phytochemical-based triphenylphosphonium (TPP A library of phytochemical-based TPP Structure-activity-toxicity data revealed the contributions of the different structural components (phenolic ring, carbon-based spacers, carboxamide group, alkyl linker) to the compounds' bioactivity and safety. Dihydrocinnamic derivatives 5 m and 5n stood out as safe, potent and selective antibacterial agents against S. aureus (MIC < 0.25 µg/mL; CC Collectively, these studies demonstrate the potential of phytochemical-based TPP

Identifiants

DOI: 10.1016/j.jare.2023.02.004 PMID: 36822390 PMC: PMC10704080
pubmed: 36822390
pii: S2090-1232(23)00055-3
doi: 10.1016/j.jare.2023.02.004
pmc: PMC10704080
pii:
doi:

Substances chimiques

Ionic Liquids 0
Anti-Bacterial Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

251-269

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

Copyright © 2023. Production and hosting by Elsevier B.V.

Références

J Biomol Screen. 1999;4(2):67-73
pubmed: 10838414
Chem Rev. 2017 Aug 9;117(15):10043-10120
pubmed: 28654243
Biochim Biophys Acta. 2016 May;1858(5):936-46
pubmed: 26577273
ACS Appl Bio Mater. 2020 Sep 21;3(9):6400-6407
pubmed: 35021771
PLoS One. 2015 Apr 30;10(4):e0121837
pubmed: 25927600
Int J Mol Sci. 2015 Feb 06;16(2):3626-55
pubmed: 25667977
Eur J Med Chem. 2019 Apr 1;167:525-545
pubmed: 30784884
Talanta. 2005 Apr 30;66(3):670-3
pubmed: 18970037
J Biol Chem. 2018 Feb 2;293(5):1536-1549
pubmed: 29255091
Microb Drug Resist. 2015 Dec;21(6):600-9
pubmed: 25734256
Front Chem. 2018 Apr 23;6:126
pubmed: 29740575
J Med Chem. 2020 Dec 24;63(24):15243-15257
pubmed: 33152241
Sci Rep. 2017 May 3;7(1):1394
pubmed: 28469140
Free Radic Biol Med. 2022 Feb 1;179:119-132
pubmed: 34954022
Diagn Microbiol Infect Dis. 2014 Jun;79(2):125-34
pubmed: 24717959
Chem Res Toxicol. 2017 Jan 17;30(1):13-37
pubmed: 27617882
PLoS Pathog. 2021 Mar 31;17(3):e1009468
pubmed: 33788901
J Med Chem. 2022 Apr 14;65(7):5625-5641
pubmed: 35311294
Chem Rev. 2017 Oct 11;117(19):12415-12474
pubmed: 28953368
J Med Chem. 2020 Dec 24;63(24):15693-15708
pubmed: 33325700
Regul Toxicol Pharmacol. 2013 Dec;67(3):456-67
pubmed: 24080225
Microb Drug Resist. 2013 Aug;19(4):256-65
pubmed: 23480526
Biochemistry (Mosc). 2015 Dec;80(12):1589-97
pubmed: 26638684
Eur J Med Chem. 2022 Mar 5;231:114135
pubmed: 35085925
Antioxidants (Basel). 2018 Aug 08;7(8):
pubmed: 30096848
Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7326-7331
pubmed: 29941569
J Agric Food Chem. 2000 Jun;48(6):2122-6
pubmed: 10888509
Redox Biol. 2021 Sep;45:102037
pubmed: 34147843
Int J Food Microbiol. 2009 Oct 31;135(2):144-51
pubmed: 19733929
J Med Chem. 2017 Aug 24;60(16):7084-7098
pubmed: 28745898
Int J Mol Sci. 2021 Dec 22;23(1):
pubmed: 35008507
ACS Infect Dis. 2015 Jul 10;1(7):285-7
pubmed: 27622818
Biochem Biophys Res Commun. 1973 Sep 18;54(2):796-9
pubmed: 4585693
Biophys J. 2007 May 1;92(9):3178-94
pubmed: 17293394
Biochim Biophys Acta Biomembr. 2017 Mar;1859(3):377-387
pubmed: 28011176
J Med Chem. 2020 Nov 12;63(21):12171-12195
pubmed: 32520557
J Med Chem. 2021 Sep 9;64(17):12903-12916
pubmed: 34432450
Nat Methods. 2009 Aug;6(8):569-75
pubmed: 19644458
Molecules. 2019 Aug 01;24(15):
pubmed: 31375003
Curr Top Microbiol Immunol. 2017;404:1-44
pubmed: 26919863
Chem Sci. 2020 Feb 12;11(10):2627-2639
pubmed: 32206266
Sci Rep. 2017 Jul 28;7(1):6842
pubmed: 28754950

Auteurs

Daniel Chavarria (D)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.

Anabela Borges (A)

LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal; ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.

Sofia Benfeito (S)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.

Lisa Sequeira (L)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.

Marta Ribeiro (M)

LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.

Catarina Oliveira (C)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.

Fernanda Borges (F)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.

Manuel Simões (M)

LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal; ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal. Electronic address: mvs@fe.up.pt.

Fernando Cagide (F)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal. Electronic address: fborges@fc.up.pt.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Phytochemicals and quaternary phosphonium...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › Phytochemicals and quaternary phosphonium...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Phytochemicals and quaternary phosphonium...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Liquides ioniques › Phytochemicals and quaternary phosphonium...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Phytochemicals and quaternary phosphonium...
questionsmedicales.fr › Bactéries › Phytochemicals and quaternary phosphonium...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Phytochemicals and quaternary phosphonium...