Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques.


Journal

NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863

Informations de publication

Date de publication:
23 Feb 2023
Historique:
received: 05 09 2022
accepted: 09 02 2023
entrez: 23 2 2023
pubmed: 24 2 2023
medline: 24 2 2023
Statut: epublish

Résumé

Despite the availability of several effective SARS-CoV-2 vaccines, additional vaccines will be required for optimal global vaccination. In this study, we investigate the immunogenicity and protective efficacy of the GBP510 protein subunit vaccine adjuvanted with AS03, which has recently been authorized for marketing in South Korea under the trade name SKYCovione

Identifiants

pubmed: 36823160
doi: 10.1038/s41541-023-00622-0
pii: 10.1038/s41541-023-00622-0
pmc: PMC9947939
doi:

Types de publication

Journal Article

Langues

eng

Pagination

23

Informations de copyright

© 2023. The Author(s).

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Auteurs

Catherine Jacob-Dolan (C)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, 02115, USA.

Jingyou Yu (J)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Katherine McMahan (K)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Victoria Giffin (V)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Abishek Chandrashekar (A)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Amanda J Martinot (AJ)

Tufts Cummings School of Veterinary Medicine, North Grafton, MA, 01536, USA.

Tochi Anioke (T)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Olivia C Powers (OC)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Kevin Hall (K)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

David Hope (D)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Jessica Miller (J)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Nichole P Hachmann (NP)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Benjamin Chung (B)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Sarah Gardner (S)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Daniel Sellers (D)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Julia Barrett (J)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Mark G Lewis (MG)

Bioqual, Rockville, MD, 20852, USA.

Hanne Andersen (H)

Bioqual, Rockville, MD, 20852, USA.

Harry Kleanthous (H)

Bill and Melinda Gates Foundation, Seattle, WA, 98109, USA.

Ki-Woen Seo (KW)

Department of Research and Development, SK bioscience 310 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.

Su Jeen Lee (SJ)

Department of Research and Development, SK bioscience 310 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.

Yong Wook Park (YW)

Department of Research and Development, SK bioscience 310 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.

Hun Kim (H)

Department of Research and Development, SK bioscience 310 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.

Dan H Barouch (DH)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA. dbarouch@bidmc.harvard.edu.
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. dbarouch@bidmc.harvard.edu.
Harvard Medical School, Boston, MA, 02115, USA. dbarouch@bidmc.harvard.edu.

Classifications MeSH