Genomic evidence for adaptation to tuberculosis in the Andes before European contact.
Anthropology
Evolutionary biology
Human genetics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
17 Feb 2023
17 Feb 2023
Historique:
received:
13
07
2022
revised:
11
11
2022
accepted:
17
01
2023
entrez:
24
2
2023
pubmed:
25
2
2023
medline:
25
2
2023
Statut:
epublish
Résumé
Most studies focusing on human high-altitude adaptation in the Andean highlands have thus far been focused on Peruvian populations. We present high-coverage whole genomes from Indigenous people living in the Ecuadorian highlands and perform multi-method scans to detect positive natural selection. We identified regions of the genome that show signals of strong selection to both cardiovascular and hypoxia pathways, which are distinct from those uncovered in Peruvian populations. However, the strongest signals of selection were related to regions of the genome that are involved in immune function related to tuberculosis. Given our estimated timing of this selection event, the Indigenous people of Ecuador may have adapted to
Identifiants
pubmed: 36824277
doi: 10.1016/j.isci.2023.106034
pii: S2589-0042(23)00111-6
pmc: PMC9941198
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106034Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Bioinformatics. 2017 Jul 15;33(14):2148-2155
pubmed: 28334108
Nature. 2014 Oct 23;514(7523):494-7
pubmed: 25141181
Genome Res. 2012 Sep;22(9):1813-31
pubmed: 22955991
Gigascience. 2021 Feb 16;10(2):
pubmed: 33590861
Sci Adv. 2018 Nov 08;4(11):eaau4921
pubmed: 30417096
Tuberculosis (Edinb). 2016 Mar;97:118-25
pubmed: 26611659
Bioinformatics. 2016 Sep 15;32(18):2817-23
pubmed: 27283948
Nat Genet. 2006 Aug;38(8):904-9
pubmed: 16862161
Am J Hum Genet. 2013 Aug 8;93(2):278-88
pubmed: 23910464
Am J Hum Genet. 2022 Apr 7;109(4):727-737
pubmed: 35298920
Wien Med Wochenschr. 2005 Apr;155(7-8):157-62
pubmed: 15966261
Am J Hum Genet. 2017 Nov 2;101(5):752-767
pubmed: 29100088
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Nat Genet. 2019 Sep;51(9):1321-1329
pubmed: 31477933
Nat Commun. 2017 Mar 01;8:14644
pubmed: 28248292
Biotechniques. 1991 Apr;10(4):506-13
pubmed: 1867860
Am J Hum Genet. 2007 Nov;81(5):1084-97
pubmed: 17924348
Mol Ecol Resour. 2017 Jan;17(1):78-90
pubmed: 27863062
PLoS One. 2015 May 11;10(5):e0125444
pubmed: 25961286
Elife. 2019 Oct 22;8:
pubmed: 31637998
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Mol Cell. 2017 Jun 15;66(6):772-779
pubmed: 28622522
Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4189-4194
pubmed: 28373541
Nat Commun. 2021 Oct 12;12(1):5942
pubmed: 34642312
Nature. 2007 Oct 18;449(7164):913-8
pubmed: 17943131
Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24006-24011
pubmed: 31712437
J Cell Physiol. 2001 Feb;186(2):260-7
pubmed: 11169463
Science. 2020 Sep 11;369(6509):1318-1330
pubmed: 32913098
PLoS Biol. 2006 Mar;4(3):e72
pubmed: 16494531
J Clin Invest. 2003 Mar;111(5):681-9
pubmed: 12618522
Nucleic Acids Res. 2010 Sep;38(16):e164
pubmed: 20601685
Nature. 2002 Oct 24;419(6909):832-7
pubmed: 12397357
Nature. 2016 Oct 13;538(7624):201-206
pubmed: 27654912
Science. 2014 Oct 24;346(6208):466-9
pubmed: 25342802
Bioinformatics. 2011 Nov 1;27(21):3070-1
pubmed: 21926124
Tuberculosis (Edinb). 2012 May;92(3):248-52
pubmed: 22297026
Eur J Immunol. 2017 Mar;47(3):432-445
pubmed: 28150302
Mol Biol Evol. 2022 Aug 3;39(8):
pubmed: 35860855
Bioinformatics. 2011 Aug 1;27(15):2156-8
pubmed: 21653522
PLoS Genet. 2012;8(11):e1002967
pubmed: 23166502
Med Microbiol Immunol. 2020 Aug;209(4):545-552
pubmed: 32440787
Mol Biol Evol. 2013 Aug;30(8):1877-88
pubmed: 23666210
PLoS Genet. 2006 Dec;2(12):e190
pubmed: 17194218
PLoS Genet. 2022 Apr 11;18(4):e1010134
pubmed: 35404934
PLoS Genet. 2019 Sep 13;15(9):e1008384
pubmed: 31518343
Sci Adv. 2018 Oct 17;4(10):eaat5869
pubmed: 30345355
Genome Res. 2009 Sep;19(9):1655-64
pubmed: 19648217
Cell. 2018 Nov 15;175(5):1185-1197.e22
pubmed: 30415837
Mol Biol Evol. 2018 Feb 1;35(2):299-311
pubmed: 29099937
PLoS Biol. 2013 Sep;11(9):e1001666
pubmed: 24086110
J Biol Chem. 1995 Aug 18;270(33):19458-64
pubmed: 7642629
Science. 2015 Aug 21;349(6250):aab3884
pubmed: 26198033
Bioinformatics. 2010 Nov 15;26(22):2867-73
pubmed: 20926424
Front Immunol. 2018 Oct 01;9:2246
pubmed: 30327653
Int J Paleopathol. 2020 Jun;29:128-140
pubmed: 31964606
Nat Genet. 2010 Jul;42(7):565-9
pubmed: 20562875
Nat Commun. 2016 Nov 15;7:13175
pubmed: 27845766
J Immunol. 2020 Jul 15;205(2):533-538
pubmed: 32513851
Sci Rep. 2020 Apr 10;10(1):6237
pubmed: 32277077