Characterization, evolution and risk factors of diabetes and prediabetes in a pediatric cohort of renal and liver transplant recipients.
diabetes
glucocorticoids
hyperglycemia
impaired glucose tolerance
insulin resistance
liver transplantation
renal transplantation
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
10
2022
accepted:
17
01
2023
entrez:
24
2
2023
pubmed:
25
2
2023
medline:
25
2
2023
Statut:
epublish
Résumé
Hyperglycemia (HG) and prediabetes are rarely sought in pediatric liver (LT) and renal (RT) transplantation, yet their presence indicates a high risk of diabetes and cardiovascular disease. The objectives of our DIABGRAFT study were to retrospectively (rDIABGRAFT) and longitudinally (pDIABGRAFT) characterize HG and (pre)diabetes in a cohort of children with LT or/and RT. We retrospectively analyzed risk factors of HG from 195 children with LT from 2012 to 2019 and twenty children with RT from 2005 to 2019 at Cliniques universitaires Saint-Luc. In addition, we prospectively followed four LT and four RT children to evaluate the evolution of their glucose metabolism. Our rDIABGRAFT study showed that 25% and 35% of LT and RT children respectively presented transient HG and 20% of RT developed diabetes. The occurrence of HG was associated with the use of glucocorticoids and with acute events as graft rejection and infection. In our pDIABGRAFT cohort, biological markers of diabetes were in the normal range for HbA Our study shows that children with LT and RT were more at risk of developing HG when glucocorticoids were required and that HbA NCT05464043.
Sections du résumé
Background
UNASSIGNED
Hyperglycemia (HG) and prediabetes are rarely sought in pediatric liver (LT) and renal (RT) transplantation, yet their presence indicates a high risk of diabetes and cardiovascular disease. The objectives of our DIABGRAFT study were to retrospectively (rDIABGRAFT) and longitudinally (pDIABGRAFT) characterize HG and (pre)diabetes in a cohort of children with LT or/and RT.
Methods
UNASSIGNED
We retrospectively analyzed risk factors of HG from 195 children with LT from 2012 to 2019 and twenty children with RT from 2005 to 2019 at Cliniques universitaires Saint-Luc. In addition, we prospectively followed four LT and four RT children to evaluate the evolution of their glucose metabolism.
Results
UNASSIGNED
Our rDIABGRAFT study showed that 25% and 35% of LT and RT children respectively presented transient HG and 20% of RT developed diabetes. The occurrence of HG was associated with the use of glucocorticoids and with acute events as graft rejection and infection. In our pDIABGRAFT cohort, biological markers of diabetes were in the normal range for HbA
Conclusion
UNASSIGNED
Our study shows that children with LT and RT were more at risk of developing HG when glucocorticoids were required and that HbA
ClinicalTrialsgov ID
UNASSIGNED
NCT05464043.
Identifiants
pubmed: 36824650
doi: 10.3389/fped.2023.1080905
pmc: PMC9941739
doi:
Banques de données
ClinicalTrials.gov
['NCT05464043']
Types de publication
Journal Article
Langues
eng
Pagination
1080905Informations de copyright
© 2023 Welsch, Mailleux, le Hardy de Beaulieu, Ranguelov, Godefroid, Robert, Stephenne, Scheers, Reding, Sokal and Lysy.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Brain Sci. 2020 Feb 27;10(3):
pubmed: 32120784
Eur J Endocrinol. 2018 Oct 01;179(4):R207-R218
pubmed: 30299889
Transplantation. 2021 Nov 1;105(11):2470-2481
pubmed: 33560726
Kidney Int. 2005 Jun;67(6):2415-21
pubmed: 15882287
Diabetes Care. 2022 Jan 1;45(Suppl 1):S17-S38
pubmed: 34964875
Endocrinol Metab Clin North Am. 2014 Mar;43(1):75-102
pubmed: 24582093
Acta Paediatr. 2001 Jun;90(6):618-22
pubmed: 11440092
Lancet. 2003 Dec 20;362(9401):2068-70
pubmed: 14697809
Nephrol Dial Transplant. 2016 Mar;31(3):495-505
pubmed: 26538615
Diabetologia. 1985 Jul;28(7):412-9
pubmed: 3899825
Transplantation. 2001 Sep 27;72(6):1020-4
pubmed: 11579294
J Biomed Inform. 2009 Apr;42(2):377-81
pubmed: 18929686
Kidney Int. 2002 Oct;62(4):1440-6
pubmed: 12234317
Diabetes Care. 2017 Jan;40(Suppl 1):S11-S24
pubmed: 27979889
Liver Transpl. 2008 Apr;14(4):469-77
pubmed: 18383091
Transplant Proc. 2001 Aug;33(5A Suppl):8S-18S
pubmed: 11498199
J Clin Endocrinol Metab. 2011 Jun;96(6):1789-96
pubmed: 21411550
Diabet Med. 2022 Feb;39(2):e14720
pubmed: 34652870
Transplantation. 2000 Aug 15;70(3):405-10
pubmed: 10949177
BMJ. 2000 May 6;320(7244):1240-3
pubmed: 10797032
Crit Care. 2013 Mar 06;17(2):305
pubmed: 23470218
Diabetes Res Clin Pract. 2021 Feb;172:108605
pubmed: 33333203
Clin Diabetes Endocrinol. 2019 May 9;5:5
pubmed: 31086677
Diabetes Care. 2002 Mar;25(3):583-92
pubmed: 11874952
Ann Hum Biol. 2009 Nov-Dec;36(6):680-94
pubmed: 19919503
Pediatr Transplant. 2022 Mar;26(2):e14170
pubmed: 34656076
Am J Transplant. 2014 Sep;14(9):1992-2000
pubmed: 25307034
Pediatr Nephrol. 2002 Jan;17(1):1-5
pubmed: 11793126
Transplantation. 2015 Jun;99(6):1243-9
pubmed: 25539465
Transplantation. 2012 Aug 27;94(4):377-82
pubmed: 22820698
J Biomed Inform. 2019 Jul;95:103208
pubmed: 31078660
BMJ Open Diabetes Res Care. 2020 Jan;8(1):
pubmed: 31958298
Pediatr Crit Care Med. 2004 Jul;5(4):329-36
pubmed: 15215001
Lancet. 2012 Jun 16;379(9833):2279-90
pubmed: 22683128
Endocrinol Metab (Seoul). 2017 Jun;32(2):180-189
pubmed: 28555464
Arq Bras Endocrinol Metabol. 2012 Jul;56(5):275-84
pubmed: 22911279
Rev Infect Dis. 1989 Nov-Dec;11(6):954-63
pubmed: 2690289
Children (Basel). 2021 Jul 16;8(7):
pubmed: 34356579