Association between carotid intima-media thickness and cognitive decline differs by race.
ELSA-Brasil
carotid intima-media thickness
cognitive decline
epidemiology
race
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
medline:
11
8
2023
pubmed:
25
2
2023
entrez:
24
2
2023
Statut:
ppublish
Résumé
Common carotid intima-media thickness (cIMT) is a marker of subclinical atherosclerosis and is associated with cognitive decline. Although carotid atherosclerosis is more frequent in White than in Black participants, little is known whether race modifies the association between cIMT and cognitive decline. In this longitudinal analysis of the ELSA-Brasil, we assessed cIMT using ultrasound and cognitive performance using different domain tests. We used linear mixed models, interaction analysis, and race stratified analyses. Baseline high IMT values were associated with memory (p < 0.001), verbal fluency (p < 0.001), TMT-B (p < 0.001)), and global cognitive decline (p < 0.001). Race was an effect modifier in the association between IMT and global cognitive decline (0.043), with stronger association in White (p < 0.001) than in Black (p = 0.009) participants. Baseline IMT was associated with global and domain-specific cognitive decline and race modified this relationship, with stronger associations in White participants. Carotid intima-media thickness (cIMT) was associated with cognitive decline. cIMT and cognitive decline association was stronger in White than in Black participants. We used inverse probability weighting to address attrition bias.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3528-3536Informations de copyright
© 2023 the Alzheimer's Association.
Références
Polak JF, O'Leary DH. Carotid intima-media thickness as surrogate for and predictor of CVD. Glob Heart. 2016;11:295. doi:10.1016/j.gheart.2016.08.006
Gepner AD, Young R, Delaney JA, et al. Comparison of coronary artery calcium presence, carotid plaque presence, and carotid intima-media thickness for cardiovascular disease prediction in the multi-ethnic study of atherosclerosis. Circ Cardiovasc Imaging. 2015;8. doi:10.1161/CIRCIMAGING.114.002262
Wendell CR, Waldstein SR, Evans MK, Zonderman AB. Subclinical carotid atherosclerosis and neurocognitive function in an urban population. Atherosclerosis. 2016;249:125-131. doi:10.1016/j.atherosclerosis.2016.04.009
Suemoto CK, Santos IS, Bittencourt MS, et al. Subclinical carotid artery atherosclerosis and performance on cognitive tests in middle-aged adults: Baseline results from the ELSA-Brasil. Atherosclerosis. 2015;243:510-515. doi:10.1016/j.atherosclerosis.2015.10.008
Wendell CR, Waldstein SR, Ferrucci L, O'Brien RJ, Strait JB, Zonderman AB. Carotid atherosclerosis and prospective risk of dementia. Stroke. 2012;43:3319-3324. doi:10.1161/STROKEAHA.112.672527
Sander K, Bickel H, Förstl H, et al. Carotid- intima media thickness is independently associated with cognitive decline. The INVADE study. Int J Geriatr Psychiatry. 2010;25:389-394. doi:10.1002/gps.2351
Wendell CR, Zonderman AB, Metter EJ, Najjar SS, Waldstein SR. Carotid intimal medial thickness predicts cognitive decline among adults without clinical vascular disease. Stroke. 2009;40:3180-3185. doi:10.1161/STROKEAHA.109.557280
Xiang J, Zhang T, Yang Q, et al. Carotid artery atherosclerosis is correlated with cognitive impairment in an elderly urban Chinese non-stroke population. J Clin Neurosci. 2013;20:1571-1575. doi:10.1016/j.jocn.2013.02.026
Sacco RL, Roberts JK, Boden-Albala B, et al. Race-ethnicity and determinants of carotid atherosclerosis in a multiethnic population: the Northern Manhattan Stroke Study. Stroke. 1997;28:929-935. doi:10.1161/01.STR.28.5.929
Rockman CB, Hoang H, Guo Y, et al. The prevalence of carotid artery stenosis varies significantly by race. J Vasc Surg. 2013;57:327-337. doi:10.1016/j.jvs.2012.08.118
Lal BK, Meschia JF, Brott TG, et al. Race differences in high-grade carotid artery stenosis. Stroke. 2021;52:2053-2059. doi:10.1161/STROKEAHA.120.032723
Steffen BT, Thanassoulis G, Duprez D, et al. Race-based differences in lipoprotein(a)-associated risk of carotid atherosclerosis: the multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol. 2019;39:523-529. doi:10.1161/ATVBAHA.118.312267
De Anda-Duran I, Alonso CF, Libon DJ, et al. Carotid intima-media thickness and midlife cognitive function: impact of race and social disparities in the bogalusa heart study. Neurology. 2022. doi:10.1212/WNL.0000000000200155
Aquino EML, Barreto SM, Bensenor IM, et al. Brazilian longitudinal study of adult health (ELSA-Brasil): objectives and design. Am J Epidemiol. 2012;175:315-324. doi:10.1093/aje/kwr294
Schmidt MI, Duncan BB, Mill JG, et al. Cohort profile: longitudinal study of adult health (ELSA-Brasil). Int J Epidemiol. 2015;44:68-75. doi:10.1093/ije/dyu027
Santos IS, Bittencourt MS, Oliveira IRS, et al. Carotid intima-media thickness value distributions in The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Atherosclerosis. 2014;237:227-235. doi:10.1016/j.atherosclerosis.2014.09.004
Mill JG, Pinto K, Griep RH, et al. Afericoes e exames clinicos realizados nos participantes do ELSA-Brasil. Rev Saúde Pública. 2013;47:54-62. doi:10.1590/S0034-8910.2013047003851
de Passos VM A, Caramelli P, Benseñor I, Giatti L, Barreto SM. Methods of cognitive function investigation in the Longitudinal Study on Adult Health (ELSA-Brasil). Sao Paulo Med J. 2014;132:170-177. doi:10.1590/1516-3180.2014.1323646
de Menezes ST, Giatti L, Brant LCC, et al. Hypertension, prehypertension, and hypertension control: association with decline in cognitive performance in the ELSA-Brasil cohort. Hypertension. 2021;77:672-681. doi:10.1161/HYPERTENSIONAHA.120.16080
Bertola L, Benseñor IM, Barreto SM, et al. Measurement invariance of neuropsychological tests across different sociodemographic backgrounds in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Neuropsychology. 2020;34:227-234. doi:10.1037/neu0000597
Drehmer M, Pereira MA, Schmidt MI, et al. Total and full-fat, but not low-fat, dairy product intakes are inversely associated with metabolic syndrome in adults. J Nutr. 2016;146:81-89. doi:10.3945/jn.115.220699
Duinkerken E, Moreno AB, Eto FN, et al. Biopsychosocial factors associated with a current depressive episode in diabetes: the ELSA-Brasil study. Diabet Med. 2020:dme.14349. doi:10.1111/dme.14349
Pitanga FJG, Matos SMA, Almeida M da C, Barreto SM, Aquino EML. Leisure-time physical activity, but not commuting physical activity, is associated with cardiovascular risk among ELSA-Brasil participants. Arq Bras Cardiol. 2017. doi:10.5935/abc.20170178
Hernan MA, Robins JM. Causal Inference: What If. Boca Raton: Chapman & Hall/CRC; 2020.
Hofman A, Ott A, Breteler MM, et al. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet North Am Ed. 1997;349:151-154. doi:10.1016/S0140-6736(96)09328-2
Feinkohl I, Keller M, Robertson CM, et al. Clinical and subclinical macrovascular disease as predictors of cognitive decline in older patients with type 2 diabetes. Diabetes Care. 2013;36:2779-2786. doi:10.2337/dc12-2241
Moon JH, Lim S, Han JW, et al. Carotid intima-media thickness is associated with the progression of cognitive impairment in older adults. Stroke. 2015;46:1024-1030. doi:10.1161/STROKEAHA.114.008170
Frazier DT, Seider T, Bettcher BM, et al. The role of carotid intima-media thickness in predicting longitudinal cognitive function in an older adult cohort. Cerebrovasc Dis. 2014;38:441-447. doi:10.1159/000366469
Sperling R, Mormino E, Johnson K. The evolution of preclinical Alzheimer's disease: implications for prevention trials. Neuron. 2014;84:608-622. doi:10.1016/j.neuron.2014.10.038
Suemoto CK, Bertola L, Grinberg LT, et al. Education, but not occupation, is associated with cognitive impairment: the role of cognitive reserve in a sample from a low-to-middle-income country. Alzheimers Dement. 2022;18:2079-2087. doi:10.1002/alz.12542
Cermakova P, Ding J, Meirelles O, et al. Carotid intima-media thickness and markers of brain health in a biracial middle-aged cohort: CARDIA brain MRI sub-study. J Gerontol Ser A. 2020;75:380-386. doi:10.1093/gerona/glz039
Duncombe J, Kitamura A, Hase Y, Ihara M, Kalaria RN, Horsburgh K. Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia. Clin Sci. 2017;131:2451-2468. doi:10.1042/CS20160727
Della-Morte D, Dong C, Markert MS, et al. Carotid intima-media thickness is associated with White matter hyperintensities: the Northern Manhattan Study. Stroke. 2018;49:304-311. doi:10.1161/STROKEAHA.117.018943
Roseborough AD, Saad L, Goodman M, Cipriano LE, Hachinski VC, Whitehead SN. White matter hyperintensities and longitudinal cognitive decline in cognitively normal populations and across diagnostic categories: a meta-analysis, systematic review, and recommendations for future study harmonization. Alzheimers Dement J Alzheimers Assoc. 2023;19:194-207. doi:10.1002/alz.12642
Inkeri J, Tynjälä A, Forsblom C, et al. Carotid intima-media thickness and arterial stiffness in relation to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes. Acta Diabetol. 2021;58:929-937. doi:10.1007/s00592-021-01678-x
Mukadam N, Marston L, Lewis G, Livingston G. Risk factors, ethnicity and dementia: a UK Biobank prospective cohort study of White, South Asian and Black participants. PLoS One. 2022;17:e0275309. doi:10.1371/journal.pone.0275309
Zahodne LB, Sharifian N, Kraal AZ, et al. Socioeconomic and psychosocial mechanisms underlying racial/ethnic disparities in cognition among older adults. Neuropsychology. 2021;35:265-275. doi:10.1037/neu0000720
Liu X, Dhana K, Barnes LL, et al. A healthy plant-based diet was associated with slower cognitive decline in African American older adults: a biracial community-based cohort. Am J Clin Nutr. 2022;116:875-886. doi:10.1093/ajcn/nqac204
Dhana K, Barnes LL, Agarwal P, et al. Vitamin D intake and cognitive decline in Blacks and Whites: the role of diet and supplements. Alzheimers Dement. 2023;19:1135-1142. doi:10.1002/alz.12729
Babulal GM, Quiroz YT, Albensi BC, et al. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: update and areas of immediate need. Alzheimers Dement. 2019;15:292-312. doi:10.1016/j.jalz.2018.09.009