Sarcopenia of kidney transplant recipients as a predictive marker for reduced graft function and graft survival after kidney transplantation.
Graft survival
HUAC
Kidney function
Kidney transplantation
Sarcopenia
Journal
Langenbeck's archives of surgery
ISSN: 1435-2451
Titre abrégé: Langenbecks Arch Surg
Pays: Germany
ID NLM: 9808285
Informations de publication
Date de publication:
24 Feb 2023
24 Feb 2023
Historique:
received:
07
07
2022
accepted:
13
02
2023
entrez:
24
2
2023
pubmed:
25
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
The association between sarcopenia of kidney transplant recipients and outcome after kidney transplantation (KT) has not yet been fully understood and is still considered controversial. The aim of our study was to analyze the impact of pre-transplant sarcopenia on graft function, postoperative complication rates, and survival of the patients after renal transplantation. In this retrospective single-center study, all patients who underwent KT (01/2013-12/2017) were included. Demographic data, rejection rates, delayed graft function, and graft and patient survival rates were analyzed. Sarcopenia was measured in computed tomography images by the sex-adjusted Hounsfield unit average calculation (HUAC). During the study period, 111 single KTs (38 women and 73 men) were performed. Living donor kidney transplants were performed in 48.6%. In total, 32.4% patients had sarcopenia. Sarcopenic patients were significantly older (59.6 years vs. 49.8 years; p < 0.001), had a higher body mass index (BMI = 27.6 kg/m At the time of kidney transplantation, sarcopenia was found to predict reduced long-term graft function and diminished graft survival after KT. The early identification of sarcopenic patients can not only enable an optimized selection of recipients, but also the initiation of pre-habilitation programs during the waiting period.
Identifiants
pubmed: 36826595
doi: 10.1007/s00423-023-02836-1
pii: 10.1007/s00423-023-02836-1
pmc: PMC9958183
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103Informations de copyright
© 2023. The Author(s).
Références
Health Qual Life Outcomes. 2013 May 30;11:88
pubmed: 23721430
Ann Surg Oncol. 2021 Nov;28(12):7185-7195
pubmed: 33876359
Front Nutr. 2019 Nov 12;6:169
pubmed: 31781571
Am J Transplant. 2013 Jun;13(6):1549-56
pubmed: 23601159
Clin Transplant. 2017 Mar;31(3):
pubmed: 28075034
Clin Exp Nephrol. 2020 Apr;24(4):379-383
pubmed: 31875933
J Chronic Dis. 1987;40(5):373-83
pubmed: 3558716
Clin Transplant. 2015 Feb;29(2):167-75
pubmed: 25377026
BMC Geriatr. 2021 Dec 23;21(1):730
pubmed: 34949161
Nephrol Dial Transplant. 2008 Sep;23(9):2995-3003
pubmed: 18408075
Eur Radiol. 2014 May;24(5):998-1005
pubmed: 24535076
J Cachexia Sarcopenia Muscle. 2022 Feb;13(1):86-99
pubmed: 34816624
Clin Nutr. 2021 May;40(5):2809-2816
pubmed: 33933747
Ann Surg Oncol. 2018 May;25(5):1160-1166
pubmed: 29404820
Am J Transplant. 2011 Oct;11(10):2093-109
pubmed: 21883901
J Nutr Health Aging. 2009 Oct;13(8):724-8
pubmed: 19657557
Ann Surg Oncol. 2022 Mar;29(3):1553-1563
pubmed: 34716836
World J Surg. 2018 Oct;42(10):3364-3371
pubmed: 29691621
Clin J Am Soc Nephrol. 2011 Jun;6(6):1463-73
pubmed: 21415312
J Gastrointest Surg. 2015 Sep;19(9):1593-602
pubmed: 25925237
Liver Transpl. 2013 Nov;19(11):1172-80
pubmed: 23960026
Transplant Proc. 2022 Sep;54(7):1816-1821
pubmed: 35933230
Transplantation. 2008 Aug 15;86(3):391-8
pubmed: 18698241
Transplant Direct. 2020 Sep 25;6(10):e610
pubmed: 33062843
N Engl J Med. 1999 Dec 2;341(23):1725-30
pubmed: 10580071
JAMA Netw Open. 2021 Aug 2;4(8):e2115274
pubmed: 34459908
World J Surg. 2021 Jul;45(7):2218-2226
pubmed: 33842995
Cancers (Basel). 2022 Jan 05;14(1):
pubmed: 35008425
Ann Surg. 2004 Aug;240(2):205-13
pubmed: 15273542
Curr Opin Nephrol Hypertens. 2022 Nov 1;31(6):560-565
pubmed: 36172855
JAMA. 1993 Sep 15;270(11):1339-43
pubmed: 8360969
Clin Nutr. 2017 Jun;36(3):663-671
pubmed: 27371993
Eur J Surg Oncol. 2018 May;44(5):658-663
pubmed: 29428474
J Thorac Dis. 2021 Mar;13(3):1358-1369
pubmed: 33841929
Nephrourol Mon. 2014 Jul 05;6(4):e20055
pubmed: 25695027
Am J Nephrol. 2022;53(6):427-434
pubmed: 35584614
Am J Kidney Dis. 2019 Mar;73(3 Suppl 1):A7-A8
pubmed: 30798791
Front Nutr. 2022 May 13;9:896427
pubmed: 35634393
Nutrients. 2022 Jun 05;14(11):
pubmed: 35684154
World J Urol. 2021 Jun;39(6):2223-2230
pubmed: 32785765
Clin Res Hepatol Gastroenterol. 2021 Jul;45(4):101692
pubmed: 33848672
Int Urol Nephrol. 2022 Aug;54(8):1977-1986
pubmed: 35028810
World J Gastrointest Surg. 2016 Jan 27;8(1):27-40
pubmed: 26843911
Am J Transplant. 2013 Aug;13(8):2091-5
pubmed: 23731461
Tech Coloproctol. 2019 Sep;23(9):877-885
pubmed: 31486988
Transplant Rev (Orlando). 2014 Oct;28(4):188-92
pubmed: 25154797
Clin Nutr ESPEN. 2017 Dec;22:76-80
pubmed: 29415839
Colorectal Dis. 2015 Nov;17(11):O256-64
pubmed: 26194849
J Korean Med Sci. 2022 May 09;37(18):e146
pubmed: 35535373