Mathematical Model of Antibiotic Resistance Determinants' Stability Under Space Flight Conditions.
Antibiotic resistance
E. coli
International space station
SALYUT 7
Space conditions
Stability model
Journal
Astrobiology
ISSN: 1557-8070
Titre abrégé: Astrobiology
Pays: United States
ID NLM: 101088083
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
medline:
7
4
2023
pubmed:
25
2
2023
entrez:
24
2
2023
Statut:
ppublish
Résumé
Increasing antibiotic resistance (AR) poses dangers of treatment complications and even treatment failure to astronauts. An AR determinant is a gene of resistance carried by bacteria. This article considers the issue of the stability of AR determinants and the influence of manned spaceflight conditions on this characteristic. A phenomenological model has been developed that makes it possible to evaluate the integral value of the stability of determinants of AR in bacteria as a function of time. Based on experimental results obtained during implementation of the SALYUT 7 space program, the stability of determinants of AR in
Identifiants
pubmed: 36827596
doi: 10.1089/ast.2022.0076
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM