Synthesis and characterization of cellulose functionalized zeolitic diatomite as an enhanced carrier of oxaliplatin drug; loading, release, and cytotoxicity.
Cellulose
Cytotoxicity
Diatomite
Loading
Oxaliplatin
Zeolite
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
30 Apr 2023
30 Apr 2023
Historique:
received:
22
01
2023
revised:
11
02
2023
accepted:
20
02
2023
medline:
10
4
2023
pubmed:
25
2
2023
entrez:
24
2
2023
Statut:
ppublish
Résumé
Natural diatomite frustules (D) were incorporated in zeolitization and cellulose functionalization processes to obtain zeolitized diatomite (ZD) and cellulose fibrous/zeolitized diatomite composite (CF/ZD). The modified products were assessed as potential carriers of oxaliplatin drug (OXPL) with enhanced properties. The prepared ZD (112.5 mg/g) and CF/ZD (268.3 mg/g) structures exhibit significantly enhanced encapsulation capacities as compared to raw diatomite (65.9 mg/g). The occurred encapsulation reactions follow the classic Pseudo-first order kinetic (R
Identifiants
pubmed: 36828091
pii: S0141-8130(23)00719-5
doi: 10.1016/j.ijbiomac.2023.123825
pii:
doi:
Substances chimiques
Oxaliplatin
04ZR38536J
diatomite
68855-54-9
Cellulose
9004-34-6
Zeolites
1318-02-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123825Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.