Phytochemical investigation of Scutellaria scordiifolia and its trypanocidal activity.

Scutellaria / chemistry Glycosides / pharmacology Flavones / pharmacology Glucosides / chemistry Iridoids / chemistry Phytochemicals / pharmacology
Chrysin C-glycoside Iridoid glucoside Lamiaceae Phenanthrene glucoside Scutellaria scordiifolia Trypanosoma congolense

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
May 2023
Historique:
received: 16 09 2022
revised: 17 02 2023
accepted: 19 02 2023
medline: 31 3 2023
pubmed: 25 2 2023
entrez: 24 2 2023
Statut: ppublish

Résumé

Scutellaria scordiifolia Fisch. ex Schrank is used to treat various inflammatory diseases and other ailments in traditional and contemporary medicine. In this study, 10 undescribed compounds, including a flavanone (1), four chrysin C-glycosides (2-5), a phenanthrene glucoside (6), four iridoid glucosides (7-10) and 31 known compounds were identified from an extract of the aerial parts of S. scordiifolia. The absolute configurations of sugars in C-glycosides were determined by comparing electric circular dichroism spectra with calculated data. The flavanones (1 and 17), flavonols (11-13), flavone (14), and some of the flavone glucuronides (15, 16) exhibited trypanocidal activities against Trypanosoma congolense. The activity data and quantitative HPLC analysis of flavonoids from the aerial parts of S. scordiifolia suggest that they may effectively treat diseases caused by the aforementioned trypanosomes. Other compounds such as novel iridoids and phenanthrene glycosides, which may be useful for chemophenetic and chemoecological discussions, were also identified.

Identifiants

DOI: 10.1016/j.phytochem.2023.113615 PMID: 36828100
pubmed: 36828100
pii: S0031-9422(23)00031-6
doi: 10.1016/j.phytochem.2023.113615
pii:
doi:

Substances chimiques

Glycosides 0
Flavones 0
Glucosides 0
Iridoids 0
Phytochemicals 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113615

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Stipan Nurbyek (S)

Division of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai, 981-8558, Japan; School of Engineering and Applied Sciences, National University of Mongolia, Ulaanbaatar, 14201, Mongolia.

Buyanmandakh Buyankhishig (B)

Division of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai, 981-8558, Japan; School of Engineering and Applied Sciences, National University of Mongolia, Ulaanbaatar, 14201, Mongolia.

Keisuke Suganuma (K)

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, 080-8555, Japan.

Yoshinobu Ishikawa (Y)

Faculty of Pharmaceutical Sciences, Shonan University of Medical Sciences, 16-48 Kamishinano, Totsuka-ku, Yokohama, 244-0806, Japan.

Mika Kutsuma (M)

Division of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai, 981-8558, Japan.

Marie Abe (M)

Division of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai, 981-8558, Japan.

Kenroh Sasaki (K)

Division of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai, 981-8558, Japan.

Bekh-Ochir Davaapurev (BO)

School of Engineering and Applied Sciences, National University of Mongolia, Ulaanbaatar, 14201, Mongolia.

Javzan Batkhuu (J)

School of Engineering and Applied Sciences, National University of Mongolia, Ulaanbaatar, 14201, Mongolia.

Toshihiro Murata (T)

Division of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai, 981-8558, Japan. Electronic address: murata-t@tohoku-mpu.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Lamiaceae › Scutellaria › Phytochemical investigation of Scutellaria...
questionsmedicales.fr › Glucides › Hétérosides › Phytochemical investigation of Scutellaria...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavones › Phytochemical investigation of Scutellaria...
questionsmedicales.fr › Glucides › Hétérosides › Glucosides › Phytochemical investigation of Scutellaria...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrannes › Iridoïdes › Phytochemical investigation of Scutellaria...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Phytochemical investigation of Scutellaria...