[Involvement of inorganic phosphate starvation in Pseudomonas aeruginosa bacterial virulence].
Implication de la carence en phosphates inorganiques dans la virulence bactérienne de Pseudomonas aeruginosa.
Infection
Phosphate
Virulence
Journal
Revue des maladies respiratoires
ISSN: 1776-2588
Titre abrégé: Rev Mal Respir
Pays: France
ID NLM: 8408032
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
05
01
2023
accepted:
06
01
2023
pubmed:
25
2
2023
medline:
28
3
2023
entrez:
24
2
2023
Statut:
ppublish
Résumé
Pseudomonas aeruginosa is a bacterium causing a wide spectrum of nosocomial and opportunistic respiratory infections. As an element essential for bacterial metabolism , phosphorus is incorporated as an inorganic phosphate and regulated by a two-component PhoB-PhoR system. Recently, it has been shown that as a result of overexpression of virulence factors, including the PhoB transcription factor, P. aeruginosa exhibited increased virulence in phosphate-deficient conditions. Exploration of the relationship between phosphate homeostasis and P. aeruginosa virulence could effectively contribute to the development of new, simple and innovative therapeutic strategies.
Identifiants
pubmed: 36828680
pii: S0761-8425(23)00042-6
doi: 10.1016/j.rmr.2023.01.019
pii:
doi:
Substances chimiques
Phosphates
0
Bacterial Proteins
0
Types de publication
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
243-246Informations de copyright
Copyright © 2023 SPLF. Published by Elsevier Masson SAS. All rights reserved.