Genetic insights into the neurobiology of anxiety.
anxiety disorder
brain
gene expression
genome-wide association study
mouse model
stress
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
15
09
2022
revised:
20
01
2023
accepted:
30
01
2023
pubmed:
25
2
2023
medline:
25
3
2023
entrez:
24
2
2023
Statut:
ppublish
Résumé
Anxiety and fear are evolutionarily conserved emotions that increase the likelihood of an organism surviving threatening situations. Anxiety and vigilance states are regulated by neural networks involving multiple brain regions. In anxiety disorders, this intricate regulatory system is disturbed, leading to excessive or prolonged anxiety or fear. Anxiety disorders have both genetic and environmental risk factors. Genetic research has the potential to identify specific genetic variants causally associated with specific phenotypes. In recent decades, genome-wide association studies (GWASs) have revealed variants predisposing to neuropsychiatric disorders, suggesting novel neurobiological pathways in the etiology of these disorders. Here, we review recent human GWASs of anxiety disorders, and genetic studies of anxiety-like behavior in rodent models. These studies are paving the way for a better understanding of the neurobiological mechanisms underlying anxiety disorders.
Identifiants
pubmed: 36828693
pii: S0166-2236(23)00023-1
doi: 10.1016/j.tins.2023.01.007
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
318-331Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests I.H. is listed as an inventor on a pending patent application regarding a panic disorder biomarker. M-K.K. declares no conflicts of interest.