Do dried blood spots have the potential to support result management processes in routine sports drug testing?-Part 3: LC-MS/MS-based peptide analysis for dried blood spot sampling time point estimation.

DBS LC-HRMS/MS age estimation anti-doping control peptide analysis

Journal

Drug testing and analysis
ISSN: 1942-7611
Titre abrégé: Drug Test Anal
Pays: England
ID NLM: 101483449

Informations de publication

Date de publication:
24 Feb 2023
Historique:
revised: 21 02 2023
received: 02 01 2023
accepted: 21 02 2023
pubmed: 26 2 2023
medline: 26 2 2023
entrez: 25 2 2023
Statut: aheadofprint

Résumé

Along with the recent acknowledgement of the World Anti-Doping Agency to use dried blood spot (DBS) samples for routine doping control purposes, there have been propositions to use DBS as a matrix that allows regular proactive remotely supervised self-sampling, providing potential longitudinal monitoring of an athlete's exposure to doping agents. However, several organizational aspects have to be considered before implementation, such as the verification of the sample collections time point. Based on a previous untargeted proteomics workflow utilizing liquid chromatography-high-resolution mass spectrometry (LC-HRMS) to identify protein/peptide markers to define the time since deposition of a bloodstain, the aim of the current study was to develop a targeted LC-HRMS/MS analytical method for promising peptidic target analytes. A long-term DBS storage experiment was carried out over a 3-month period (sample collection time points: 0, 2, 4, 7, 14, 21, 28, 42, 56, 70, 84 and 91 days) with DBS samples of 10 volunteers for longitudinal investigation of signal abundance changes of targeted peptide sequences at different storage temperatures (room temperature [RT], 4°C and -20°C). Prior to experimental analysis, LC-HRMS/MS method characteristics were successfully assessed, including intraday precision, carryover and sample extract stability. For estimation of DBS sample collection time points, ratios of two peptides that originate from the same protein prior to tryptic digestion were created. Two targeted peptide area ratios were found to significantly increase after being stored at RT for 28 days, representing potential markers for future use in routine doping controls that contribute to advancing complementary avenues in anti-doping.

Identifiants

pubmed: 36829300
doi: 10.1002/dta.3463
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Bundesministerium des Innern, für Bau und Heimat, Berlin, Germany
Organisme : Manfred Donike Institut für Dopinganalytik e.V.

Informations de copyright

© 2023 The Authors. Drug Testing and Analysis published by John Wiley & Sons Ltd.

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Auteurs

Lana Brockbals (L)

Center for Preventive Doping Research, Institute of Biochemistry, German Sports University Cologne, Am Sportpark Muengersdorf, Cologne, Germany.

Andreas Thomas (A)

Center for Preventive Doping Research, Institute of Biochemistry, German Sports University Cologne, Am Sportpark Muengersdorf, Cologne, Germany.

Tom D Schneider (TD)

Department of Forensic Pharmacology and Toxicology, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland.

Thomas Kraemer (T)

Department of Forensic Pharmacology and Toxicology, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland.

Andrea E Steuer (AE)

Department of Forensic Pharmacology and Toxicology, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland.

Mario Thevis (M)

Center for Preventive Doping Research, Institute of Biochemistry, German Sports University Cologne, Am Sportpark Muengersdorf, Cologne, Germany.
European Monitoring Center for Emerging Doping Agents, Cologne, Germany.

Classifications MeSH