Using SXRF and LA-ICP-TOFMS to Explore Evidence of Treatment and Physiological Responses to Leprosy in Medieval Denmark.
calcium
dental tissues
lead
leprosy treatment
mineral imbalances
zinc
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
25 Jan 2023
25 Jan 2023
Historique:
received:
09
12
2022
revised:
19
01
2023
accepted:
20
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Leprosy can lead to blood depletion in Zn, Ca, Mg, and Fe and blood enrichment in Cu. In late medieval Europe, minerals were used to treat leprosy. Here, physiological responses to leprosy and possible evidence of treatment are investigated in enamel, dentine, and cementum of leprosy sufferers from medieval Denmark (n = 12) and early 20th century Romania (n = 2). Using SXRF and LA-ICP-TOFMS, 12 elements were mapped in 15 tooth thin sections, and the statistical covariation of paired elements was computed to assess their biological relevance. The results show marked covariations in the Zn, Ca, and Mg distributions, which are compatible with clinical studies but cannot be directly attributed to leprosy. Minerals used historically as a treatment for leprosy show no detectable intake (As, Hg) or a diffuse distribution (Pb) related to daily ingestion. Intense Pb enrichments indicate acute incorporations of Pb, potentially through the administration of Pb-enriched medication or the mobilization of Pb from bone stores to the bloodstream during intense physiological stress related to leprosy. However, comparisons with a healthy control group are needed to ascertain these interpretations. The positive correlations and the patterns observed between Pb and essential elements may indicate underlying pathophysiological conditions, demonstrating the potential of SXRF and LA-ICP-TOFMS for paleopathological investigations.
Identifiants
pubmed: 36829463
pii: biology12020184
doi: 10.3390/biology12020184
pmc: PMC9952905
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsches Elektronen-Synchrotron
ID : Proposal I-20190203
Organisme : Aarhus Universitets Forskningsfond
ID : AUFF-E-2015-FLS-8-2
Organisme : Université de Bordeaux
ID : GPR "Human Past"
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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