Extracellular Vesicles as Regulators of the Extracellular Matrix.
calcification
extracellular matrix
extracellular vesicles
tissue repair
tumor microenvironment
Journal
Bioengineering (Basel, Switzerland)
ISSN: 2306-5354
Titre abrégé: Bioengineering (Basel)
Pays: Switzerland
ID NLM: 101676056
Informations de publication
Date de publication:
19 Jan 2023
19 Jan 2023
Historique:
received:
18
12
2022
revised:
15
01
2023
accepted:
17
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EVs interact with the extracellular matrix (ECM) which acts as a physical scaffold for the organization and function of cells. Recent work has shown that EVs can modulate and act as regulators of the ECM. This review will first discuss EV biogenesis and the mechanism by which EVs are transported through the ECM. Additionally, we discuss how EVs contribute as structural components of the matrix and as components that aid in the degradation of the ECM. Lastly, the role of EVs in influencing recipient cells to remodel the ECM in both pathological and therapeutic contexts is examined.
Identifiants
pubmed: 36829629
pii: bioengineering10020136
doi: 10.3390/bioengineering10020136
pmc: PMC9952427
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Science Foundation
ID : DMR 2132744
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