Plasma Copper Concentration Is Associated with Cardiovascular Mortality in Male Kidney Transplant Recipients.
cardiovascular
copper
kidney transplantation
mortality
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
10 Feb 2023
10 Feb 2023
Historique:
received:
05
01
2023
revised:
02
02
2023
accepted:
07
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Kidney transplant recipients (KTR) are at increased risk of cardiovascular mortality. We investigated whether, in KTR, post-transplantation copper status is associated with the risk of cardiovascular mortality and potential effect modification by sex. In this cohort study, plasma copper was measured using mass spectrometry in extensively-phenotyped KTR with a functioning allograft >1-year. Cox regression analyses with the inclusion of multiplicative interaction terms were performed. In 660 KTR (53 ± 13 years old, 56% male), the median baseline plasma copper was 15.42 (IQR 13.53-17.63) µmol/L. During a median follow-up of 5 years, 141 KTR died, 53 (38%) due to cardiovascular causes. Higher plasma copper was associated with an increased risk of cardiovascular mortality in the overall KTR population (HR 1.37; 95% CI, 1.07-1.77 per 1-SD,
Identifiants
pubmed: 36830012
pii: antiox12020454
doi: 10.3390/antiox12020454
pmc: PMC9952822
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : TiFN
ID : A-1003
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