CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD

NAD+ biosynthetic pathway NAD+-lowering agents cancer metabolism mitochondrial disfunction multiple myeloma oxidative stress

Journal

Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981

Informations de publication

Date de publication:
15 Feb 2023
Historique:
received: 28 12 2022
revised: 06 02 2023
accepted: 09 02 2023
entrez: 25 2 2023
pubmed: 26 2 2023
medline: 26 2 2023
Statut: epublish

Résumé

Cancer cells fuel growth and energy demands by increasing their NAD

Identifiants

pubmed: 36830052
pii: antiox12020494
doi: 10.3390/antiox12020494
pmc: PMC9952390
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Italian Association for Cancer Research
ID : 2328
Organisme : Italian Ministry of Health
ID : GR-2016-02361523
Organisme : Italian Association for Cancer Research
ID : 24449
Organisme : Italian Association for Cancer Research
ID : 21552

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Auteurs

Pamela Becherini (P)

Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, 16126 Genoa, Italy.

Debora Soncini (D)

Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, 16126 Genoa, Italy.

Silvia Ravera (S)

Department of Experimental Medicine (DIMES), University of Genoa, 16126 Genoa, Italy.

Elisa Gelli (E)

Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, 16126 Genoa, Italy.

Claudia Martinuzzi (C)

IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Giulia Giorgetti (G)

Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, 16126 Genoa, Italy.

Antonia Cagnetta (A)

Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, 16126 Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Fabio Guolo (F)

Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, 16126 Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Federico Ivaldi (F)

Department of Internal Medicine (DiMI), University of Genoa, 16126 Genoa, Italy.

Maurizio Miglino (M)

Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, 16126 Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Sara Aquino (S)

Hematology and Hematopoietic Stem Cell Transplantation Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Katia Todoerti (K)

Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milan, 20133 Milano, Italy.

Antonino Neri (A)

Scientific Directorate, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.

Andrea Benzi (A)

Department of Experimental Medicine (DIMES), University of Genoa, 16126 Genoa, Italy.

Mario Passalacqua (M)

Department of Experimental Medicine (DIMES), University of Genoa, 16126 Genoa, Italy.

Alessio Nencioni (A)

IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Department of Internal Medicine (DiMI), University of Genoa, 16126 Genoa, Italy.

Ida Perrotta (I)

Department of Biology, Ecology and Earth Sciences, Centre for Microscopy and Microanalysis (CM2), University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy.

Maria Eugenia Gallo Cantafio (ME)

Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.

Nicola Amodio (N)

Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.

Antonio De Flora (A)

Department of Experimental Medicine (DIMES), University of Genoa, 16126 Genoa, Italy.

Santina Bruzzone (S)

Department of Experimental Medicine (DIMES), University of Genoa, 16126 Genoa, Italy.

Roberto M Lemoli (RM)

Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, 16126 Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Michele Cea (M)

Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, 16126 Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Classifications MeSH