Evaluating the Use of Neonatal Colonization Screening for Empiric Antibiotic Therapy of Sepsis and Pneumonia.

MDR MDRGN colonization multidrug-resistant Gram-negative bacteria multidrug-resistant bacteria neonatal infection neonates pneumonia screening sepsis

Journal

Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404

Informations de publication

Date de publication:
17 Jan 2023
Historique:
received: 25 12 2022
revised: 13 01 2023
accepted: 14 01 2023
entrez: 25 2 2023
pubmed: 26 2 2023
medline: 26 2 2023
Statut: epublish

Résumé

(1) Background: Since 2013, weekly screening for multidrug-resistant Gram-negative (MDRGN) bacteria has been performed in German neonatal intensive care units (NICU). National guidelines recommend considering these colonization analyses for antibiotic treatment regimens. Our retrospective single center study provides insight into the clinical dichotomy of bacterial colonization and infection rates in neonates. (2) Methods: We analyzed microbiological data of neonates admitted to our tertiary level NICU over nine years. Colonization with MDRGN/

Identifiants

pubmed: 36830099
pii: antibiotics12020189
doi: 10.3390/antibiotics12020189
pmc: PMC9952289
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Deutsche Forschungsgemeinschaft
Organisme : Friedrich-Alexander-University of Erlangen-Nuernberg within the funding programs
Organisme : Open Access Publication Funding

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Auteurs

Alisa Bär (A)

Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-University of Erlangen-Nuernberg, Loschgestraße 15, 91054 Erlangen, Germany.

Sabina Schmitt-Grohé (S)

Division of Allergology, Pulmonology and Mucoviscidosis, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University of Erlangen-Nuernberg, Loschgestraße 15, 91054 Erlangen, Germany.

Jürgen Held (J)

Institute of Clinical Microbiology, Immunology and Hygiene, University Clinic Erlangen, Wasserturmstraße 3/5, 91054 Erlangen, Germany.

Julia Lubig (J)

Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-University of Erlangen-Nuernberg, Loschgestraße 15, 91054 Erlangen, Germany.

Gregor Hanslik (G)

Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-University of Erlangen-Nuernberg, Loschgestraße 15, 91054 Erlangen, Germany.

Fabian B Fahlbusch (FB)

Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-University of Erlangen-Nuernberg, Loschgestraße 15, 91054 Erlangen, Germany.

Heiko Reutter (H)

Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-University of Erlangen-Nuernberg, Loschgestraße 15, 91054 Erlangen, Germany.
Institute of Human Genetics University Clinic Erlangen, Friedrich-Alexander University of Erlangen-Nuernberg, 91054 Erlangen, Germany.

Joachim Woelfle (J)

Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-University of Erlangen-Nuernberg, Loschgestraße 15, 91054 Erlangen, Germany.

Adriana van der Donk (A)

Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-University of Erlangen-Nuernberg, Loschgestraße 15, 91054 Erlangen, Germany.

Maria Schleier (M)

Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-University of Erlangen-Nuernberg, Loschgestraße 15, 91054 Erlangen, Germany.

Tobias Hepp (T)

Institute for Medical Informatics, Biometry and Epidemiology (IMBE), Friedrich-Alexander-University Erlangen-Nuernberg, Waldstr. 6, 91054 Erlangen, Germany.

Patrick Morhart (P)

Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-University of Erlangen-Nuernberg, Loschgestraße 15, 91054 Erlangen, Germany.

Classifications MeSH