How to Use Nebulized Antibiotics in Severe Respiratory Infections.
nebulized antibiotic
pharmacokinetic/pharmacodynamic
respiratory tract infection
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
28 Jan 2023
28 Jan 2023
Historique:
received:
19
12
2022
revised:
18
01
2023
accepted:
19
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Difficult-to-treat pulmonary infections caused by multidrug-resistant (MDR) pathogens are of great concern because their incidence continues to increase worldwide and they are associated with high morbidity and mortality. Nebulized antibiotics are increasingly being used in this context. The advantages of the administration of a nebulized antibiotic in respiratory tract infections due to MDR include the potential to deliver higher drug concentrations to the site of infection, thus minimizing the systemic adverse effects observed with the use of parenteral or oral antibiotic agents. However, there is an inconsistency between the large amount of experimental evidence supporting the administration of nebulized antibiotics and the paucity of clinical studies confirming the efficacy and safety of these drugs. In this narrative review, we describe the current evidence on the use of nebulized antibiotics for the treatment of severe respiratory infections.
Identifiants
pubmed: 36830177
pii: antibiotics12020267
doi: 10.3390/antibiotics12020267
pmc: PMC9952454
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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