Influence of Skin Commensals on Therapeutic Outcomes of Surgically Debrided Diabetic Foot Infections-A Large Retrospective Comparative Study.
antibiotic therapy
associations with treatment failure
diabetic foot infections
non-beta-lactam antibiotics
skin commensals
treatment failures
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
03 Feb 2023
03 Feb 2023
Historique:
received:
20
12
2022
revised:
26
01
2023
accepted:
31
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
In diabetic foot infections (DFI), the clinical virulence of skin commensals are generally presumed to be low. In this single-center study, we divided the wound isolates into two groups: skin commensals (coagulase-negative staphylococci, micrococci, corynebacteria, cutibacteria) and pathogenic pathogens, and followed the patients for ≥ 6 months. In this retrospective study among 1018 DFI episodes (392 [39%] with osteomyelitis), we identified skin commensals as the sole culture isolates (without accompanying pathogenic pathogens) in 54 cases (5%). After treatment (antibiotic therapy [median of 20 days], hyperbaric oxygen in 98 cases [10%]), 251 episodes (25%) were clinical failures. Group comparisons between those growing only skin commensals and controls found no difference in clinical failure (17% vs. 24 %,
Identifiants
pubmed: 36830227
pii: antibiotics12020316
doi: 10.3390/antibiotics12020316
pmc: PMC9952192
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : University Hospital of Geneva
ID : n.a.
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