Dietary Alpha-Ketoglutarate Supplementation Improves Bone Growth, Phosphorus Digestion, and Growth Performance in Piglets.
alpha-ketoglutarate
apparent digestibility of phosphorus
bone growth
piglets
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
06 Feb 2023
06 Feb 2023
Historique:
received:
03
01
2023
revised:
31
01
2023
accepted:
03
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Phosphorus (P) pollution from modern swine production is a major environmental problem. Dietary interventions to promote bone growth can improve the utilization of dietary P, and thereby reduce its emission. Recent in vitro studies have shown that alpha-ketoglutarate (AKG) exerts a pro-osteogenic effect on osteoblast cells. This study aimed to evaluate the effects of AKG supplementation on bone growth, P and Ca digestion, and the gut microbial profile in piglets. Thirty-two piglets were randomly assigned into two dietary groups. The piglets were fed a basic diet containing 10 g/kg AKG or 10 g/kg maize starch (control) for 28 days. On days 21-28, titanium dioxide was used as an indicator to determine the apparent digestibility of P. AKG supplementation improved the bone mineral density, length, weight, and geometrical and strength properties of the femur and tibia. Furthermore, AKG supplementation increased apparent ileal and total tract digestibility of P. Colonic microbiota analysis results showed that AKG supplementation increased α-diversity and beneficial bacteria, including
Identifiants
pubmed: 36830356
pii: ani13040569
doi: 10.3390/ani13040569
pmc: PMC9951703
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 32130099
Organisme : Key Programs of Frontier Scientific Research of the Chinese Academy of Sciences
ID : QYZDY-SSW-SMC008
Organisme : TaiShan Industrial Experts Program
ID : Permit No. SA 2020045
Références
Bone. 1993 May-Jun;14(3):265-70
pubmed: 8363866
Int J Mol Sci. 2020 Feb 12;21(4):
pubmed: 32059605
J Anim Physiol Anim Nutr (Berl). 2020 Jan;104(1):300-309
pubmed: 31674084
Arch Anim Nutr. 2020 Feb;74(1):39-56
pubmed: 31552757
J Leukoc Biol. 2021 Sep;110(3):525-537
pubmed: 33884666
JAMA. 2001 Feb 14;285(6):785-95
pubmed: 11176917
Animals (Basel). 2020 Sep 25;10(10):
pubmed: 32992813
Food Funct. 2022 Jul 4;13(13):7046-7061
pubmed: 35678197
J Anim Sci. 2022 Sep 1;100(9):
pubmed: 35961010
J Anim Sci. 2017 Oct;95(10):4490-4498
pubmed: 29108069
J Int Soc Prev Community Dent. 2018 Mar-Apr;8(2):168-173
pubmed: 29780743
Anim Sci J. 2018 May;89(5):802-809
pubmed: 29405491
Nat Commun. 2018 Jan 4;9(1):55
pubmed: 29302038
J Anim Sci. 2011 Jun;89(6):1844-52
pubmed: 21278113
Bone. 1993 Jul-Aug;14(4):595-608
pubmed: 8274302
Adv Exp Med Biol. 2017;1033:47-58
pubmed: 29101651
Nat Commun. 2020 Nov 5;11(1):5596
pubmed: 33154378
Water Res. 2021 Nov 28;209:117906
pubmed: 34896811
Gut Microbes. 2022 Jan-Dec;14(1):2020068
pubmed: 35040746
J Anim Sci Biotechnol. 2019 May 28;10:47
pubmed: 31149337
Food Funct. 2020 Jan 29;11(1):472-482
pubmed: 31833510
N Engl J Med. 2008 Jul 3;359(1):61-73
pubmed: 18596274
Nat Rev Drug Discov. 2009 Feb;8(2):139-52
pubmed: 19165233
Animals (Basel). 2020 Apr 22;10(4):
pubmed: 32331362
Dev Period Med. 2016 Jan-Mar;20(1):61-7
pubmed: 27416627
Environ Sci Pollut Res Int. 2022 Apr;29(18):27479-27495
pubmed: 34982382
Arch Anim Nutr. 2019 Dec;73(6):457-471
pubmed: 31454268
Cell Host Microbe. 2018 Dec 12;24(6):833-846.e6
pubmed: 30543778
J Dent Res. 2010 Dec;89(12):1333-48
pubmed: 20924069
Poult Sci. 2005 Oct;84(10):1604-9
pubmed: 16335130
J Agric Food Chem. 2016 Apr 6;64(13):2668-73
pubmed: 27018713
J Anim Sci. 2020 Dec 1;98(12):
pubmed: 33205812
Toxicol Appl Pharmacol. 2019 Jul 1;374:53-64
pubmed: 31051157
Arch Immunol Ther Exp (Warsz). 2017 Feb;65(1):21-36
pubmed: 27326424
J Anim Physiol Anim Nutr (Berl). 2009 Dec;93(6):669-77
pubmed: 18700848
J Anim Sci. 2004 Jan;82(1):179-83
pubmed: 14753360
J Nutr. 2007 Jul;137(7):1795-801
pubmed: 17585033
Crit Rev Food Sci Nutr. 2017 Jun 13;57(9):1922-1937
pubmed: 25976422
Annu Rev Pathol. 2011;6:121-45
pubmed: 20936937
Trends Microbiol. 2017 Oct;25(10):851-873
pubmed: 28602521
Animal. 2020 Aug;14(S2):s313-s322
pubmed: 32605676
Curr Opin Immunol. 2018 Apr;51:62-67
pubmed: 29525347
Animals (Basel). 2020 Jan 21;10(2):
pubmed: 31973009
Nutrients. 2023 Jan 30;15(3):
pubmed: 36771407
Animal. 2013 Jul;7(7):1067-78
pubmed: 23410993