Oligodendrocyte Progenitors Display Enhanced Proliferation and Autophagy after Space Flight.
HSP-90
SPARC
autophagy
intracranial hypertension
oligodendrocyte progenitors
proliferation
space flight
visual impairment intracranial pressure
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
19 01 2023
19 01 2023
Historique:
received:
27
12
2022
revised:
15
01
2023
accepted:
17
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Intracranial hypertension (ICP) and visual impairment intracranial pressure (VIIP) are some of the consequences of long-term space missions. Here we examined the behavior of oligodendrocyte progenitors (OLPs) after space flight using time-lapse microscopy. We show that most OLPs divided more than ground control (GC) counterparts did. Nonetheless, a subpopulation of OLPs flown to space presented a significant increase in autophagic cell death. Examination of the proteomic profile of the secretome of space flown OLPs (SPC-OLPs) revealed that the stress protein heat shock protein-90 beta "HSP-90β" was the 5
Identifiants
pubmed: 36830573
pii: biom13020201
doi: 10.3390/biom13020201
pmc: PMC9953055
pii:
doi:
Substances chimiques
Osteonectin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Références
Radiother Oncol. 2016 May;119(2):265-75
pubmed: 26993419
Development. 1998 Aug;125(16):3143-52
pubmed: 9671587
Sci Rep. 2017 Nov 15;7(1):15648
pubmed: 29142208
Int J Oncol. 2013 Jan;42(1):188-96
pubmed: 23123816
Biochim Biophys Acta. 2012 Mar;1823(3):730-41
pubmed: 21982864
Apoptosis. 2019 Oct;24(9-10):812-825
pubmed: 31359205
Top Curr Chem. 2013;328:155-240
pubmed: 22955504
PLoS One. 2013 Dec 04;8(12):e76963
pubmed: 24324574
Front Biosci (Schol Ed). 2016 Jan 01;8(1):29-43
pubmed: 26709894
Int J Cancer. 2008 Jun 15;122(12):2735-43
pubmed: 18350569
Int J Mol Sci. 2018 Aug 29;19(9):
pubmed: 30158430
Bone. 2014 Apr;61:125-31
pubmed: 24463210
Cells. 2019 Nov 12;8(11):
pubmed: 31726662
Neuron. 1998 May;20(5):869-82
pubmed: 9620692
Exp Hematol. 2004 Aug;32(8):773-81
pubmed: 15308329
Dev Cell. 2004 Apr;6(4):463-77
pubmed: 15068787
Life (Basel). 2022 May 27;12(6):
pubmed: 35743828
Int J Mol Sci. 2022 Nov 18;23(22):
pubmed: 36430810
Curr Protoc Stem Cell Biol. 2016 Nov;39(1):2D.18.1-2D.18.28
pubmed: 31816188
Lancet Neurol. 2018 Sep;17(9):802-815
pubmed: 30129476
Development. 1989 Feb;105(2):387-400
pubmed: 2680425