Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases.
chronic joint pain
inflammation
lipidomics
metabolic status
synovial fluid
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
09 02 2023
09 02 2023
Historique:
received:
02
01
2023
revised:
04
02
2023
accepted:
06
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Lipids, especially lysophosphatidylcholine LPC16:0, have been shown to be involved in chronic joint pain through the activation of acid-sensing ion channels (ASIC3). The aim of the present study was to investigate the lipid contents of the synovial fluids from controls and patients suffering from chronic joint pain in order to identify characteristic lipid signatures associated with specific joint diseases. For this purpose, lipids were extracted from the synovial fluids and analyzed by mass spectrometry. Lipidomic analyses identified certain choline-containing lipid classes and molecular species as biomarkers of chronic joint pain, regardless of the pathology, with significantly higher levels detected in the patient samples. Moreover, correlations were observed between certain lipid levels and the type of joint pathologies. Interestingly, LPC16:0 levels appeared to correlate with the metabolic status of patients while other choline-containing lipids were more specifically associated with the inflammatory state. Overall, these data point at selective lipid species in synovial fluid as being strong predictors of specific joint pathologies which could help in the selection of the most adapted treatment.
Identifiants
pubmed: 36830710
pii: biom13020342
doi: 10.3390/biom13020342
pmc: PMC9953120
pii:
doi:
Substances chimiques
Lipids
0
Biomarkers
0
Banques de données
ClinicalTrials.gov
['NCT01867840']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-17-CE16-0018
Organisme : Association Française contre les Myopathies
ID : 23731
Organisme : Agence Nationale de la Recherche
ID : ANR-11-LABX-0015-01
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