Endocannabinoid Degradation Enzyme Inhibitors as Potential Antipsychotics: A Medicinal Chemistry Perspective.
FAAH inhibitors
MGL inhibitors
drug-likeness
endocannabinoid system
hERG
ligand efficiency metrics
repositioning
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
06 Feb 2023
06 Feb 2023
Historique:
received:
09
01
2023
revised:
28
01
2023
accepted:
30
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
The endocannabinoid system (ECS) plays a very important role in numerous physiological and pharmacological processes, such as those related to the central nervous system (CNS), including learning, memory, emotional processing, as well pain control, inflammatory and immune response, and as a biomarker in certain psychiatric disorders. Unfortunately, the half-life of the natural ligands responsible for these effects is very short. This perspective describes the potential role of the inhibitors of the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL), which are mainly responsible for the degradation of endogenous ligands in psychic disorders and related pathologies. The examination was carried out considering both the impact that the classical exogenous ligands such as Δ
Identifiants
pubmed: 36831006
pii: biomedicines11020469
doi: 10.3390/biomedicines11020469
pmc: PMC9953700
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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