Prospective Evaluation of CD45RA+/CCR7- Effector Memory T (T
TEMRA cells
brain metastases
cytomegalovirus (CMV)
glioblastoma
infection
radiotherapy
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
04 02 2023
04 02 2023
Historique:
received:
29
11
2022
revised:
20
01
2023
accepted:
01
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Radiotherapy (RT) of the brain is a common treatment for patients with high-grade gliomas and brain metastases. It has previously been shown that reactivation of cytomegalovirus (CMV) frequently occurs during RT of the brain. This causes neurological decline, demands antiviral treatment, and is associated with a worse prognosis. CMV-specific T cells are characterized by a differentiated effector memory phenotype and CD45RA+ CCR7- effector memory T (T
Identifiants
pubmed: 36831183
pii: cells12040516
doi: 10.3390/cells12040516
pmc: PMC9954596
pii:
doi:
Substances chimiques
Receptors, CCR7
0
Leukocyte Common Antigens
EC 3.1.3.48
CCR7 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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