FGF23 in Chronic Kidney Disease: Bridging the Heart and Anemia.
anemia
cardiovascular risk
chronic kidney disease
erythropoietin
fibroblast growth factor 23
heart
iron deficiency
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
13 02 2023
13 02 2023
Historique:
received:
28
12
2022
revised:
09
02
2023
accepted:
10
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced mainly in osteocytes. In chronic kidney disease (CKD) FGF23 levels increase due to higher production, but also as the result of impaired cleavage and reduced excretion from the body. FGF23 has a significant role in disturbed bone and mineral metabolism in CKD, which leads to a higher cardiovascular risk and mortality in these patients. Current research has emphasized the expression of FGF23 in cardiac myocytes, fibroblasts, and endothelial cells, and in addition to the effects on the kidney, its primary role is in cardiac remodeling in CKD patients. Recent discoveries found a significant link between increased FGF23 levels and anemia development in CKD. This review describes the FGF23 role in cardiac hypertrophy and anemia in the setting of CKD and discusses the best therapeutical approach for lowering FGF23 levels.
Identifiants
pubmed: 36831276
pii: cells12040609
doi: 10.3390/cells12040609
pmc: PMC9954184
pii:
doi:
Substances chimiques
FGF23 protein, human
0
Fibroblast Growth Factor-23
7Q7P4S7RRE
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Kidney Int. 2019 Oct;96(4):813-815
pubmed: 31543148
Front Endocrinol (Lausanne). 2018 May 28;9:278
pubmed: 29892269
Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E38-49
pubmed: 16449303
Sci Rep. 2017 Jun 13;7(1):3345
pubmed: 28611350
FASEB J. 2018 Jul;32(7):3752-3764
pubmed: 29481308
Nephrol Dial Transplant. 2018 Oct 1;33(10):1722-1734
pubmed: 29425341
FASEB J. 2016 Feb;30(2):994-1001
pubmed: 26527066
Cells. 2021 May 20;10(5):
pubmed: 34065339
Ann Palliat Med. 2022 Apr;11(4):1264-1277
pubmed: 34775773
Kidney Int. 2010 Nov;78(10):975-80
pubmed: 20844473
Kidney Res Clin Pract. 2020 Sep 30;39(3):334-343
pubmed: 32839355
Circ Res. 2004 Jan 9;94(1):110-8
pubmed: 14656927
PLoS One. 2017 Oct 26;12(10):e0186979
pubmed: 29073196
Biomed Res Int. 2018 Aug 12;2018:9481475
pubmed: 30159331
Semin Dial. 2021 May;34(3):183-195
pubmed: 33592133
Oncotarget. 2016 Oct 4;7(40):64649-64664
pubmed: 27579618
J Am Soc Nephrol. 2015 May;26(5):1150-60
pubmed: 25475745
Curr Opin Nephrol Hypertens. 2022 Jul 1;31(4):339-343
pubmed: 35703173
Nat Rev Nephrol. 2019 Mar;15(3):159-175
pubmed: 30664681
Front Endocrinol (Lausanne). 2018 May 02;9:189
pubmed: 29770125
Am J Kidney Dis. 2017 Jun;69(6):815-826
pubmed: 28242135
Kidney Int. 2010 Oct;78(7):679-85
pubmed: 20613714
J Ren Nutr. 2009 Jan;19(1):69-72
pubmed: 19121775
PLoS One. 2020 Apr 21;15(4):e0231905
pubmed: 32315372
Sci Rep. 2018 May 8;8(1):7294
pubmed: 29740119
Curr Opin Nephrol Hypertens. 2019 Jul;28(4):304-310
pubmed: 31145704
Mol Endocrinol. 2009 Sep;23(9):1505-18
pubmed: 19556340
Kidney Int. 2016 Nov;90(5):985-996
pubmed: 27457912
Curr Opin Rheumatol. 2011 Nov;23(6):562-7
pubmed: 21885974
Metabolism. 2020 Feb;103S:153865
pubmed: 30664852
JCI Insight. 2018 Dec 6;3(23):
pubmed: 30518682
Int J Biochem Cell Biol. 2017 Nov;92:63-78
pubmed: 28919046
Pflugers Arch. 2016 Sep;468(9):1621-35
pubmed: 27448998
Nephrol Dial Transplant. 2014 Aug;29(8):1525-32
pubmed: 24459137
Am J Nephrol. 2017;45(1):49-59
pubmed: 27889746
J Bone Miner Res. 2013 Aug;28(8):1793-803
pubmed: 23505057
Nephrol Dial Transplant. 2011 Apr;26(4):1346-54
pubmed: 20813767
Front Med (Lausanne). 2015 Sep 03;2:59
pubmed: 26389119
Nephrol Dial Transplant. 2022 Sep 22;37(10):1857-1867
pubmed: 35482713
Physiol Rep. 2020 Jun;8(11):e14434
pubmed: 32476270
Front Cell Dev Biol. 2022 Jan 18;9:791479
pubmed: 35118076
Cardiorenal Med. 2015 Oct;5(4):254-66
pubmed: 26648942
Nephrol Dial Transplant. 2022 Jan 25;37(2):211-221
pubmed: 34459924
PLoS One. 2012;7(9):e44161
pubmed: 22970174
Kidney Int. 2016 Jan;89(1):135-46
pubmed: 26535997
J Am Soc Nephrol. 2017 Jun;28(6):1851-1858
pubmed: 28082519
J Bone Miner Res. 2013 Jan;28(1):46-55
pubmed: 22886720
J Biol Chem. 2006 Mar 10;281(10):6120-3
pubmed: 16436388
Semin Dial. 2008 Jul-Aug;21(4):319-25
pubmed: 18627566
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):407-12
pubmed: 19966287
Kidney Int. 2019 Dec;96(6):1346-1358
pubmed: 31668632
Am J Nephrol. 2018;47(6):406-414
pubmed: 29874654
Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1168-74
pubmed: 26864938
Nephrol Dial Transplant. 2017 Sep 01;32(9):1493-1503
pubmed: 28339837
Clin J Am Soc Nephrol. 2017 Nov 7;12(11):1795-1803
pubmed: 28784656
Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E863-73
pubmed: 23443925
JACC Heart Fail. 2015 Oct;3(10):829-39
pubmed: 26450001
Front Med (Lausanne). 2018 Jul 24;5:206
pubmed: 30087898
Circulation. 2015 Mar 17;131(11):1019-30
pubmed: 25779542
Kidney Int. 2021 Jul;100(1):79-89
pubmed: 33811979
Cell Metab. 2015 Dec 1;22(6):1020-32
pubmed: 26437603
Nephrol Dial Transplant. 2019 Dec 1;34(12):2057-2065
pubmed: 30007314
J Clin Invest. 2011 Nov;121(11):4393-408
pubmed: 21985788
Front Endocrinol (Lausanne). 2018 Jun 12;9:320
pubmed: 29946298
J Biol Chem. 2014 Apr 4;289(14):9795-810
pubmed: 24509850
Circulation. 2015 Jul 7;132(1):27-39
pubmed: 26059012
J Clin Invest. 2012 Jul;122(7):2543-53
pubmed: 22728934
J Biol Chem. 1994 Jul 15;269(28):18320-6
pubmed: 7518429
Sci Rep. 2017 May 16;7(1):1993
pubmed: 28512310
PLoS One. 2016 Jul 11;11(7):e0156860
pubmed: 27400031
Curr Opin Nephrol Hypertens. 2016 Jul;25(4):325-32
pubmed: 27191351
Mol Cell Biol. 2007 May;27(9):3417-28
pubmed: 17339340
J Clin Endocrinol Metab. 2011 Nov;96(11):3541-9
pubmed: 21880793
J Bone Miner Res. 2015 Oct;30(10):1831-9
pubmed: 25858796
Int J Mol Sci. 2019 Aug 27;20(17):
pubmed: 31461904
Nephrol Dial Transplant. 2019 Jul 1;34(7):1115-1124
pubmed: 30380116
J Bone Miner Res. 2020 Jul;35(7):1352-1362
pubmed: 32154933
Sci Rep. 2018 Aug 17;8(1):12398
pubmed: 30120363
J Clin Med. 2020 Aug 14;9(8):
pubmed: 32823844