A Novel Blood Proteomic Signature for Prostate Cancer.
SWATH-MS
biomarkers
clinical onset
complement cascade
prostate cancer
proteomics
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
07 Feb 2023
07 Feb 2023
Historique:
received:
12
01
2023
revised:
02
02
2023
accepted:
03
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Prostate cancer is the most common malignant tumour in men. Improved testing for diagnosis, risk prediction, and response to treatment would improve care. Here, we identified a proteomic signature of prostate cancer in peripheral blood using data-independent acquisition mass spectrometry combined with machine learning. A highly predictive signature was derived, which was associated with relevant pathways, including the coagulation, complement, and clotting cascades, as well as plasma lipoprotein particle remodeling. We further validated the identified biomarkers against a second cohort, identifying a panel of five key markers (GP5, SERPINA5, ECM1, IGHG1, and THBS1) which retained most of the diagnostic power of the overall dataset, achieving an AUC of 0.91. Taken together, this study provides a proteomic signature complementary to PSA for the diagnosis of patients with localised prostate cancer, with the further potential for assessing risk of future development of prostate cancer. Data are available via ProteomeXchange with identifier PXD025484.
Identifiants
pubmed: 36831393
pii: cancers15041051
doi: 10.3390/cancers15041051
pmc: PMC9954127
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Medical Research Council
ID : MR/M008959
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5759/A25254
Pays : United Kingdom
Organisme : Punjab Educational Endowment Fund
Organisme : Blood Cancer UK
ID : Award 19007
Pays : United Kingdom
Organisme : Male Uprising / Hope for Guernsey
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