Body Shape Phenotypes and Breast Cancer Risk: A Mendelian Randomization Analysis.
Mendelian randomization
body shape
breast cancer
height
obesity
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
17 Feb 2023
17 Feb 2023
Historique:
received:
17
12
2022
revised:
11
02
2023
accepted:
15
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Observational and genetic studies have linked different anthropometric traits to breast cancer (BC) risk, with inconsistent results. We aimed to investigate the association between body shape defined by a principal component (PC) analysis of anthropometric traits (body mass index [BMI], height, weight, waist-to-hip ratio [WHR], and waist and hip circumference) and overall BC risk and by tumor sub-type (luminal A, luminal B, HER2+, triple negative, and luminal B/HER2 negative). We performed two-sample Mendelian randomization analyses to assess the association between 188 genetic variants robustly linked to the first three PCs and BC (133,384 cases/113,789 controls from the Breast Cancer Association Consortium (BCAC)). PC1 (general adiposity) was inversely associated with overall BC risk (0.89 per 1 SD [95% CI: 0.81-0.98];
Identifiants
pubmed: 36831637
pii: cancers15041296
doi: 10.3390/cancers15041296
pmc: PMC9954632
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : French National Cancer Institute
ID : INCA_14108
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